PPAR-γ在增生性瘢痕成纤维细胞中的表达及意义  

The expression and significance of PPAR-γ in hypertrophic scar fibroblasts

作　　者：潘姝[1] 李叶扬[1] 戴丽冰[2] 黄粤[1] 

机构地区：[1]暨南大学医学院第四附属医院,广东省广州市红十字会医院烧伤整形科,510220 [2]暨南大学医学院第四附属医院,广东省广州市红十字会医院创伤外科研究所,510220

出　　处：《广东医学》2009年第11期1595-1596,共2页Guangdong Medical Journal

基　　金：国家自然科学基金资助项目(编号:30600642);广州市医药卫生科技重点项目(编号:2008-ZDi-08)

摘　　要：目的探讨核转录因子过氧化物酶体增殖物激活受体-γ(PPAR-γ)在增生性瘢痕成纤维细胞中的表达状况及其意义。方法应用免疫细胞化学检测3例增生性瘢痕和正常皮肤成纤维细胞中PPAR-γ的表达。结果免疫细胞化学显示PPAR-γ蛋白在增生性瘢痕和正常皮肤成纤维细胞中均有表达,但是在增生性瘢痕中表达较正常皮肤低。结论核内受体PPAR-γ在增生性瘢痕成纤维细胞中呈下调表达,提示激活PPAR-γ可能是增生性瘢痕治疗的一种新方法。Objective To investigate the expression of peroxisome proliferator - activated receptor gamma（ PPAR - γ） in human hypertrophic sear fibroblasts and normal skin fibroblasts. Methods The expression of PPAR - γgamma were examined by immunocytoehemistry in 3 eases of hypertrophie sear and normal skin. Results Immunoeytoehemistry showed that PPAR - γ was expressed in both hypertrophic sear and normal skin fibroblasts. The level of PPAR - γprotein in hypertrophic scar fibroblasts significantly decreased. Conclusion The expression of PPAR -γ is lower in human hypertrophic scar fibroblasts than that in normal skin fibroblasts. Activating PPAR - γmay be a novel approach for the treatment of hypertrophic scar.

关 键 词：PPAR-Γ 增生性瘢痕 成纤维细胞 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学] R965[医药卫生—基础医学]