脂筏在G蛋白偶联受体信号转导中的调控作用  

Modulatory role of lipid rafts on GPCR signaling

作　　者：李莹[1] 黄思罗[1] 刘剑峰[1] 

机构地区：[1]华中科技大学生命科学与技术学院分子生物物理教育部重点实验室,湖北武汉430074

出　　处：《现代生物医学进展》2009年第18期3536-3538,共3页Progress in Modern Biomedicine

基　　金：国家教育部高等学校创新引智计划项目(B08029)资助课题

摘　　要：脂筏是细胞上富含特殊脂质和蛋白质的微结构域。随着脂筏作为细胞膜上信号传导的平台的认识,这个特征化的区域受到了越来越多的关注。大量的研究已经显示脂筏参与G蛋白偶联受体信号转导的调控。通过精细的调节G蛋白偶联受体、G蛋白和下游信号效应物等信号元件的活性,脂筏可以影响信号转导的专一性和信号偶联的效率。本综述主要介绍脂筏对G蛋白偶联受体信号转导的调控机制的研究进展。Lipid rafts are micordomains of cell membranes enriched in specific lipids and proteins. The growing interest in these specialised regions is due to the recognition that they work as platforms for plasma membrane signaling complexes. In particular, lots of evidences proved that lipid rafts are involved in the regulation of G protein coupled receptor （GPCR） signaling. Lipid rafts participate in affecting the signaling selectivity and coupling efficacy by fine-tuning of the activity of various signal components including GPCR, G protein and singaling effectors. We review recent perspective on modulatory mechanism of GPCR signaling by lipid rafts.

关 键 词：脂筏 G蛋白偶联受体 信号转导 

分 类 号：Q51[生物学—生物化学] Q257