耐辐射奇球菌辐射损伤修复机制的研究进展  

Advanceson DNA Repair Mechanisms in Reasearch of Deinococcus Radiodurans

作　　者：蒋亮[1] 李斌元[1] 

机构地区：[1]南华大学生物化学与分子生物学教研室,湖南衡阳420001

出　　处：《现代生物医学进展》2009年第18期3550-3553,3572,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金(30770647);湖南省自然科学基金(06JJ2023)

摘　　要：耐辐射奇球菌是迄今为止发现的对辐射抗性最强的原核生物,是研究DNA损伤与修复的模式生物。耐辐射奇球菌(Deinococcus radiodurans,DR)对于电离辐射、紫外线、干燥、H2O2以及其他一些DNA损伤剂均表现出极强的抵抗能力,对于这种超强抗性的具体机制,学界至今尚未形成定论。对DRDNA损伤修复机制的解释包括切除修复和重组修复。本文就耐辐射奇球菌DNA辐射损伤后修复机制的研究进展作一综述。Deinococcus radiodurans （DR） as a model organism in DNA damage and repair, is the most resistant bacterium to ionizing radiation. It is extremely resistant to a number of agents and conditions that damage DNA, including ionizing and ultraviolet （UV） radiation and hydrogen peroxide. However, little is known about the molecular mechanisms responsible for the extraordinary resistance to radiation in this organism. The possible DNA repair mechanism including excision repairing and recombination repairing. In this paper, recent research progresses on DNA repair mechanism would be summarized.

关 键 词：耐辐射奇球菌 辐射损伤 DNA修复 RecFOR途径 

分 类 号：Q936[生物学—微生物学]