酪氨酸激酶c-Abl与信号转导  

c-Abl Tyrosine Kinase in Signal Transduction

作　　者：杨尧[1] 刘萱[1] 李平[1] 马清钧[1] 曹诚[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100850

出　　处：《生物技术通讯》2009年第5期692-694,共3页Letters in Biotechnology

摘　　要：c-Abl是一种非受体型酪氨酸激酶,在细胞核和细胞质中都有分布,通过调控多种信号通路的信号转导参与多种细胞活动。细胞核中的c-Abl在DNA损伤应激中被激活并参与调控细胞凋亡,细胞质中的c-Abl参与调控细胞增殖、细胞周期、黏附迁移和细胞凋亡等细胞活动。我们简要综述了c-Abl参与调控的信号通路。c-Abl is a non-receptor tyrosine kinase located both in the nucleus and the cytoplasm.Through regulating various signaling pathways c-Abl is involved in many cell processes.In the nucleus,c-Abl protein is activated in response to DNA damage and contributes to apoptosis.Cytoplasmic c-Abl is involved in the regulation of cell proliferation,cell cycle,cell adhesion,cell migration and apoptosis.This review summarized signaling pathways regulated by c-Abl.

关 键 词：C-ABL 酪氨酸激酶 信号转导 调控 

分 类 号：Q75[生物学—分子生物学]