轻度老年性痴呆患者听功能与神经心理量表测评的关系  

The Relationships between Auditory Abilities and Outcomes of Neuropsychological Questionnaires in Patients with Alzheimer's Disease

作　　者：宋鹏龙[1] 王辉[1] 李丽[1] 张娟[1] 付欣[1] 李金兰[1] 张明霞[2] 孔峰[2] 董会卿[3] 王宁宇[1] 

机构地区：[1]首都医科大学附属北京朝阳医院耳鼻咽喉-头颈外科,北京100020 [2]首都医科大学宣武医院耳鼻咽喉-头颈外科 [3]首都医科大学宣武医院神经内科

出　　处：《听力学及言语疾病杂志》2009年第5期440-443,共4页Journal of Audiology and Speech Pathology

基　　金：北京市科技计划项目研发攻关类(NO.Z080507030808018)

摘　　要：目的探讨轻度老年性痴呆（Alzheimer’s disease，AD）患者听功能与神经心理量表测评的关系。方法测试50例正常老年人（对照组）和15例轻度AD患者（AD组）的周围听觉功能（纯音听闽、言语识别率）以及中枢听觉功能（同侧竞争信息-合成句识别试验、对侧竞争信息-合成句识别试验、交错扬扬格词试验、掩蔽级差试验），将各项神经心理量表分为言语相关性和非言语相关性两部分进行测评，分析测听结果和量表得分，比较听觉功能和神经心理量表结果之间的关系。结果AD患者周围听觉功能（纯音听阈、言语识别率）同言语相关性认知量表的关系（Kendall’s tau b分别为-0．33和0．44）比其与非言语相关性认知量表的关系（Kendall’s tau b分别为-0．23和0．26）更明显（P〈0．05），对照组中无此现象。轻度AD患者中枢听觉功能（同侧竞争信息-合成句识别试验、对侧竞争信息-合成句识别试验、交错扬扬格词试验、掩蔽级差试验）与言语相关性和非言语相关性认知量表均有明显相关性（Kendall’s tau b范围0．37-0．56），与周围听功能与言语相关性和非言语相关性认知量表关系相比较，差异有统计学意义（P〈0．05）。结论轻度AD患者的周围听功能障碍与言语相关性认知量表测评结果有关，其中枢听功能障碍与言语相关性和非言语相关性认知量表测评结果均有关，应用神经心理学量表测评轻度AD患者认知功能时，应注意听功能障碍对其结果的影响。Objective The purpose of the study is to analyze the relationships between auditory abilities and outcomes of neuropsychological questionnaires in patients with Alzheimer＇s disease. Methods 15 patients with AD and 50 normal were tested by peripheral hearing tests （PTA,WRS）, central hearing tests （SSI-ICM,SS-ICCM,SSW, MLD） and neuropsychological questionnaires. The tests of neuropsychologieal questionnaires were divided into verbal and nonverbal neuropsychometric tests. The correlation in results between hearing tests and neuropsychometric tests was analyzed by Kendall correlation analysis. Results In AID patients, the results of peripheral hearing tests had a closer relationship with verbal neuropsychometric tests （Kendall＇s tau b -0.33 and 0.44） than with central hearing tests （Kendall＇s tau b -0.23 and 0.26）. The result of central auditory tests were related both to verbal and nonverbal neuropsychometric tests （the rang of Kendall＇s tau b =0.37-0.56）. In control group,there was no correlation. Conclusion The results of verbal neuropsychometric questionaires will be affected by AD patients＇ peripheral hearing dysfunction, but not the nonverbal neuropsychometrie questionaires. Their central hearing dysfunction were related both to verbal and nonverbal neuropsychometric questionaires. The results imply the hearing dysfunction should he valued in neuropsychometric test.

关 键 词：老年性痴呆 听功能障碍 神经心理量表 言语 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]