运动对高血压大鼠肾上腺髓质素的影响及其机制  

Effect of exercises on ADM and mechanism of action in SHR

作　　者：景志强[1] 张钧[2] 

机构地区：[1]中国药科大学体育部,南京210009 [2]扬州大学运动人体科学研究所

出　　处：《中国康复医学杂志》2009年第10期914-917,共4页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:研究运动对高血压大鼠肾上腺髓质素(ADM)的影响及其作用机制。方法:将雄性自发性高血压大鼠(SHR)随机分为两组,即安静对照组和运动组,运动组SHR进行为期10周游泳运动。结果:①运动组SHR体重增长趋势明显低于对照组,运动组SHR安静血压较实验前显著降低,而对照组SHR安静血压较实验前显著升高;②运动组SHR血浆ADM含量与对照组相比显著性增加,运动组SHR血浆NO含量、cGMP含量和T-NOS活性较对照组显著性增加。结论:长期规律运动可以增加SHR血浆ADM含量,进而舒张血管降低血压,其机制可能是:ADM刺激血管内皮细胞,通过激活NOS,使NO生成增加,cGMP产生增多,使血管平滑肌松弛,血管舒张,血压降低。Objective： To study effect of exercises on plasma adrenomedullin （ADM） in spontaneously hypertensive rats （SHR）, and to explore the mechanism of ADM in depressing blood pressure through exercises. Method： Male SHR were divided into two groups randomly, control group and exercises group. Exercises group were trained with swimming for 10 weeks. Result： The resting blood pressure descended significantly in exercises group while it ascended significantly in control group, compared with that of pre-experiment. Comparing with control group,in exercises group the trend of body weight gain reduced, plasma ADM concentration increased significantly; and plasma NO concentration, T-NOS activity and eGMP production increased significantly. Conclusion： It suggests that exercises can inhibit the ascending of blood pressure by improving plasma ADM level. The possible mechanism is ADM can enhance T-NOS activity, then increased NO concentration and eGMP production.

关 键 词：高血压 运动 肾上腺髓质素 一氧化氮 

分 类 号：R455[医药卫生—运动医学] R544.1[医药卫生—治疗学]