乳腺丝氨酸蛋白酶抑制剂在口腔鳞状细胞癌中的表达及意义  

Expression of marray serine proteinase inhibitor in oral squamous cell carcinoma and its clinical significance

作　　者：罗军[1] 周岚[2] 郑根建[2] 季彤[1] 钟来平[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院口腔医学院口腔颌面外科上海市口腔医学研究所上海市口腔医学重点实验室,上海200011 [2]浙江省台州市中心医院口腔科

出　　处：《中华口腔医学杂志》2009年第10期606-610,共5页Chinese Journal of Stomatology

摘　　要：目的探讨乳腺丝氨酸蛋白酶抑制剂（marray serine proteinase inhibitor，Maspin）在口腔鳞状细胞癌中的表达及其与临床病理特征之问的关系。方法应用免疫组织化学方法对口腔鳞状细胞癌45例的癌组织及其癌旁上皮组织标本行Maspin蛋白含量的半定量测定，与各临床病理指标采用SPSS13.0统计学软件进行统计学分析。结果Maspin蛋白在口腔鳞状细胞癌组织中的表达（弱阳性31％，强阳性31％）显著低于癌旁上皮组织（弱阳性13％，强阳性87％），P=0.001；口腔鳞状细胞癌组织中Maspin蛋白的表达与淋巴结转移（P=0.038）、术后转移（P=0.004）呈负相关，与总体生存状况呈正相关（P=0.014）。结论Maspin蛋白的检测对口腔鳞状细胞癌患者判断预后具有重要价值。Objective To investigate the expression of marray serine proteinase inhibitor（Maspin） in patients with oral squamous cell carcinoma and its relationship with clinicopathological features. Methods The Maspin protein expression was examined in 45 patients with oral squamous cell carcinoma and in nonmalignant oral epithelia by immunohistocbemical staining. The relationship between the Maspin protein expression and the clinicopathological parameters was statistically analyzed. Results The Maspin protein expression in the cancerous tissues of oral squamous cell carcinoma was lower than that in the non-malignant oral epithelia （P = 0.001）. Negative correlation was found between the Maspin protein expression in cancerous tissue and the status of lymph node metastasis （ P = 0.038）. Positive Maspin protein expression indicated negative lymph node metastasis, and negative correlation was also found between the Maspin protein expression and the postoperative metastasis （ P = 0.004）. Positive correlation was found between the Maspin expression and the patients＇ survival rate （P = 0.014） , patients with positive Maspin protein expression having higher survival rate than those with negative Maspin expression. Conclusions Maspin might be useful as a potential prognostic marker for oral squamous cell carcinoma.

关 键 词：癌 鳞状细胞 丝氨酸蛋白酶抑制剂 预后 

分 类 号：R686[医药卫生—骨科学]