青少年多囊卵巢综合征患者血清转移抑制素水平与其发病的相关性  

Plasma metastin in adolescent polycystic ovary syndrome

作　　者：陈晓莉[1] 莫亚勤[1] 李琳[1] 陈亚肖[1] 李予[1] 张清学[1] 杨冬梓[1] 

机构地区：[1]中山大学附属第二医院妇产科,广州510120

出　　处：《中华妇产科杂志》2009年第10期745-749,共5页Chinese Journal of Obstetrics and Gynecology

基　　金：基金项目：国家科技支撑计划（2007BA104804）;广东省医学科研基金（B2007053、B2008042）

摘　　要：目的探讨青少年多囊卵巢综合征（PCOS）患者血清转移抑制素水平与其发病的相关性。方法收集2006年1-6月于中山大学附属第二医院妇科内分泌门诊就诊的PCOS患者42例，按年龄分为青少年组（17～19岁）19例、成年组（20～38岁）23例；同期选择16～19岁、月经正常的青春期女性20例为对照组。于月经周期第1～5天或孕激素治疗撤退性出血第1～5天（闭经者日期不限）测定3组妇女血清卵泡刺激素（FSH）、黄体生成素（LH）、睾酮、游离睾酮（FT）、硫酸脱氢表雄酮（DHEAS）、性激素结合球蛋白（SHBG）和转移抑制素水平，并计算游离雄激素指数（FAI）。次日对3组妇女行75g口服葡萄糖耐量试验和胰岛素释放试验，分别测定空腹、服糖后1h、服糖后2h的血糖及胰岛素水平，并分别计算曲线下面积（AUC）、空腹血糖与空腹胰岛素比值（GIR）和稳态模型胰岛素抵抗指数（HOMA-IR）。结果（1）内分泌激素水平比较：各组妇女的LH水平，青少年组[（12±8）U／L]和成年组[（12±7）U／L]均高于对照组[（6±4）U／L]，差异均有统计学意义（P〈0．05）；成年组的丌水平[（2．3±1．2）pmol／L]高于青少年组[（1．3±0．8）pmol／L]和对照组[（1．1±0．5）pmol／L]，青少年组的盯水平也高于对照组，差异均有统计学意义（P〈0．05）；青少年组的DHEAS水平[（3．1±2．7）μmo]／L]低于对照组[（6．3±2．7）μmol／L]，差异有统计学意义（P〈0．05）；成年组的FAI（5．6±4．1）高于对照组（3．0±1．3），差异也有统计学意义（P〈0．05）。FSH、睾酮和SHBG水平在3组间两两比较，差异均无统计学意义（P〉0．05）。（2）代谢水平及转移抑制素水平比较：青少年组的空腹、服糖后2h胰岛素水平及胰岛素AUC分别为（13±7）mU／L、（88±59）mU／L和（133±80）mU·L^-1·min^-1，均高于对照组[分别为（7±3）Objective This study was designed to investigate the eorrelationship between plasma metastin and pathogenesis of adolescent women with polycystic ovary syndrome （PCOS）. Methods From Jan. 2006 to Jun. 2006, 42 PCOS patients including 19 adolescent women and 23 adults with syndrome were treated in Second Affiliated Hospital of Sun Yat-Sen University. According to the range of age, those patients were divided into 19 cases in adolescent group （ ≤ 19 years） and 23 cases in adult group（ 〉 19 years）. Meanwhile, 20 adolescent women were matched as controls. Blood samples were collected between day 1 and day 5 of a spontaneous bleeding episode in the PCOS groups and a menstrual cycle of the controls. The levels of luteinizing hormone （ LH ）, follicle-stimulating hormone （ FSH ）, testosterone （ T ）, free T （ FT ）, dehydroepiandrosterone sulfate（ DHEAS）, sex hormone-binding globulin （ SHBG）, insulin, glucose, and metastin were detected from day 1 to day 5 of spontaneous bleeding or withdrawal bleeding by progesterone. On the next day, oral glucose tolerance test （75 g） and insulin release test were performed on those above patients and controls. The area under curve （AUC）, the ratio of fasting blood glucose to insulin （GIR） and homeostasis model assessment insulin resistance index （HOMA-1R） were calculated. Results （ 1 ） The level of hormone： the level of LH was in （12 ± 7 ）U/L in adult group and （12 ± 8）U/L in adolescent PCOS group, which were significantly higher than （6 ±4） U/L in controls（P 〈0.05）. The level of FT was （2. 3 ± 1.2） pmoL/L in adult group, which was significantly higher than （ 1.3 _± 0. 8 ） pmol/L in adolescent group and （1.1 ± 0. 5 ） pmoL/L in control group （P 〈 0. 05 ）. It was observed that the level of （3.1 ±2. 7 ）μmoL/L in adolescent group was significantly lower than （ 6. 3 ± 2. 7 ） μmol/L in control group （ P 〈 0.05 ） . Meanwhile, the level of FAI of 5.6 ± 4. 1 in adult group wa

关 键 词：多囊卵巢综合征 青春期发育 肿瘤抑制蛋白质类 

分 类 号：R686[医药卫生—骨科学]