普伐他汀与曲美他嗪联合应用对血脂水平及C-反应蛋白的影响  

作　　者：许贤德[1] 饶大勇[1] 许贤利 潘大虎[1] 季明[1] 

机构地区：[1]江苏省泗洪县分金亭医院,223900 [2]北京军区司令部门诊部,100036

出　　处：《当代医学》2009年第33期148-149,共2页Contemporary Medicine

摘　　要：目的观察普伐他汀与曲美他嗪联合应用对血脂及C-反应蛋白的影响。方法131例高脂血症或高血压病、冠心病伴高脂血症及C-反应蛋白增高的患者,随机分成普伐他汀组65例和曲美他嗪组66例。普伐他汀组患者口服普伐他汀10mg,qn。曲美他嗪组普伐他汀10mg,qn,曲美他嗪20mg,tid。两组均口服8周。检测指标:总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、脂蛋白-a(Lp-a)和超敏C-反应蛋白(hs-CRP)。结果两组治疗前后总胆固醇、甘油三脂、LDL-C、Lp-a明显降低,差异有统计学意义(P<0.05);尤其hs-CRP降低,曲美他嗪组hs-CRP降低显著(P<0.01),普伐他汀组(P<0.05)。HDL-C有不同程度的升高,但差异无统计学意义(P>0.05)。结论普伐他汀与曲美他嗪联合应用能增强普伐他汀抗炎及降脂作用。Objective To investigate the effect of combination therapy with pravastatin and trimetazidine on the level of blood lipids and C-reactive protein.Methods 131 patients with hyperlipidemia and C-reactive protein increase,partly with essential hypertension or coronary artery disease. were divided randomly into pravastatin group（n=65） and trimetazidin group （n=66）.The patients of pravastatin group received 10mg,pravastatin, qn. Trimetazidin group received 10rag, pravastatin,qn and 20mg trimetazidin, tid. The therapeutic period for each group is 8 weeks.Detection indicators： total cholesterol（TC）, triglycerides （TG）. low density liPoprotein（LDL-C）.high density lipoprotein（HDL-C）.lipoprotein-a（Lp-a）.high reactive protein （hs-CRP）. Results Compared with trimetazidin group and pravastatin group of pre- and post-therapy, TC.TG, LDL, C, Lp, a and hs-CRP are apparently decreased.there are significant statistics diference （P〈0.05）. especially hs-CRP of trimetazidin group,which had significant statistics diference （P〈0.01）. HDL-C are also increased, but there is no significant statistics diference （P〉0.05）. Conclusion The antiinflammatory and reducing sebum of pravastatin can be reinforced by combination therapy with pravastatin and trimetazidin.

关 键 词：高脂血症 普伐他汀 曲美他嗪 

分 类 号：R96[医药卫生—药理学]