神经生长因子在小鼠体内的分布与排泄实验研究  

The distribution and excretion of nerve growth factor in mice

作　　者：姜国辉[1] 唐刚华[1] 陈力真[2] 张云[2] 王世真[1] 王树惠[2] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院,北京100730 [2]中国医学科学院中国协和医科大学基础医学研究所,北京100730

出　　处：《核技术》1998年第11期649-652,共4页Nuclear Techniques

摘　　要：采用氯胺-T法对神经生长因子（Nervegrowthfactor，NGF）进行碘标记，研究了NGF在小鼠体内的分布与排泄规律。结果表明：NGF在小鼠体内组织器官的分布速率以颈上神经节、甲状腺、胆囊、肾脏、肾上腺等组织较快，各器官的达峰时间为20—30min；肌注125I－NGF72h内，小鼠粪尿中放射性排泄总量达72．55％，其中尿内累积量约占排泄总量的65.64％，而粪便中只占不足7％。Nerve growth factor(NGF) was iodolabelled with chloramine-T method and its distribution and excretion in mice were investigated. The results showed that the highest levels were found in superior cervical ganglia, thyroid, bile, kidneys and adrenals between 20-30 min after injection, and the peak time in most tissues was also found at 20-30 min. About 72.55% of the injected dose was excreted in stool and urine, among them 65.6% was excreted in urine and only 7.0% in stool within 72h after intramuscular injection.

关 键 词：神经生长因子 排泄 体内分布 碘125 碘标记 

分 类 号：R817.41[医药卫生—影像医学与核医学] R338[医药卫生—放射医学]