SPECT心血池显像评价阿霉素心肌毒性的价值  

Evaluation of myocardiotoxicity with SPECT cardiac blood pool imaging for patients treated with adriamycin

作　　者：樊卫[1] 张力[1] 梁培炎[1] 张伟光[1] 冯祝玲[1] 喻丽华[1] 

机构地区：[1]中山医科大学肿瘤医院,广州510060

出　　处：《核技术》1998年第11期672-674,共3页Nuclear Techniques

摘　　要：选择49例非何杰金淋巴瘤和小细胞肺癌等患者，采用常规CHOP和CAV方案进行治疗。定期用SPECT检测患者左心功能，评价阿霉素（ADM）对心肌的毒性作用。结果表明，化疗前后EF（射血分数）、PER（高峰射血率）和PFR（高峰充盈率）值比较，差别有显著性（P＜0.05）；体内的ADM累积量愈大，EF、PER和PFR值下降愈大，并以PFR变化最敏感。提示SPECT心功能测定是评价患者ADM心肌毒性的敏感、适用的方法。Evaluation of myocardiotoxicity on adriamycin(ADM) with SPECT cardiac blood pool imaging was presented. SPECT was done to monitor left ventricular function in 49 patients with Non-Hodgkin's Lymphoma and small cell carcinoma, they were treated with ADM of which the accumulation dose were over 300mg/m2. The results showed that parameters of EF, PER and PFR before and after treatment with ADM were 57±6%, 3.08±0.63EDV. s-1, 2.99±0.23EDV. s-1 and 50±11%, 2.25±0.66EDV. s -1, 2.53±0.35EDV. s-1 respectively. The difference of these data are significant (P<0.05). The larger the accumulative dose of ADM, the more the parameters decrease, among them PFR is the most sensitive one. It was concluded that SPECT measurement of left ventricular function is a sensitive and useful method in monitoring ADM myocardiotoxicity.

关 键 词：左心室功能测定 阿霉素 毒副作用 血池显像 

分 类 号：R817.42[医药卫生—影像医学与核医学]