Effects of five-year intensive multifactorial intervention on the serum amyloid A and macroangiopathy in patients with short-duration type 2 diabetes meUitus  

作　　者：DU Jian-ling LIU Jian-feng MEN Li-li YAO Jun-jie SUN Li-peng SUN Guo-hua SONG Gui-rong YANG Yu BAI Ran XING Qian LI Chang-chen SUN Chang-kai 

机构地区：[1]Department of Endocrinology , First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China [2]Department of Ultrasonography , First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China [3]Department of Laboratory , First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China [4]Department of Endocrinology, People's Hospital of Cangzhou, Hebei Province, Cangzhou, Hebei 061000, China [5]Department of Health Statistics, Dalian Medical University, Dalian, Liaoning 116044, China [6]Institute of Brain Disorders and the Key Lab for Brain Disorders of Liaoning Province, Dalian Medical University, Dalian, Liaoning 116044, China

出　　处：《Chinese Medical Journal》2009年第21期2560-2566,共7页中华医学杂志（英文版）

摘　　要：Background A five-year follow-up study of intensive multifactorial intervention was undertaken to assess the changes of circulating serum amyloid A （SAA） levels and the incidence of atherosclerosis （AS） in patients with short-duration type 2 diabetes mellitus （T2DM） without macroangiopathy, and whether intensive multifactorial intervention could prevent or at least postpone the occurence of macroangiopathy. Methods Among 150 patients with short-duration T2DM, 75 were assigned to receive conventional outpatient treatment （conventional group） and the others underwent intensive multifactorial integrated therapy targeting hyperglycemia, hypertension, dyslipidemia and received aspirin simultaneously （intensive group）. Results Plasma SAA levels were higher in diabetic patients than those in healthy control subjects, and decreased obviously after intensive multifactorial intervention. The levels of SAA were positively correlated with body mass index （BMI）, waist hip ratio （WHR）, triglyceride （TG）, high sensitive C-reactive protein （hs-CRP） and common carotid intima-media thickness （CC-IMT）. The standard-reaching rates of glycemia, blood pressure and lipidemia were significantly higher in intensive group than those of conventional group. The incidence of macroangiopathy decreased by 58.96% in intensive group compared with conventional group. Conclusions Intensive multifactorial intervention may significantly reduce the SAA levels and prevent the occurrence of AS in short-duration patients with T2DM. SAA might be one of the risk factors of T2DM combined with AS.Background A five-year follow-up study of intensive multifactorial intervention was undertaken to assess the changes of circulating serum amyloid A （SAA） levels and the incidence of atherosclerosis （AS） in patients with short-duration type 2 diabetes mellitus （T2DM） without macroangiopathy, and whether intensive multifactorial intervention could prevent or at least postpone the occurence of macroangiopathy. Methods Among 150 patients with short-duration T2DM, 75 were assigned to receive conventional outpatient treatment （conventional group） and the others underwent intensive multifactorial integrated therapy targeting hyperglycemia, hypertension, dyslipidemia and received aspirin simultaneously （intensive group）. Results Plasma SAA levels were higher in diabetic patients than those in healthy control subjects, and decreased obviously after intensive multifactorial intervention. The levels of SAA were positively correlated with body mass index （BMI）, waist hip ratio （WHR）, triglyceride （TG）, high sensitive C-reactive protein （hs-CRP） and common carotid intima-media thickness （CC-IMT）. The standard-reaching rates of glycemia, blood pressure and lipidemia were significantly higher in intensive group than those of conventional group. The incidence of macroangiopathy decreased by 58.96% in intensive group compared with conventional group. Conclusions Intensive multifactorial intervention may significantly reduce the SAA levels and prevent the occurrence of AS in short-duration patients with T2DM. SAA might be one of the risk factors of T2DM combined with AS.

关 键 词：serum amyloid A MACROANGIOPATHY intensive multifactorial intervention type 2 diabetes mellitus 

分 类 号：R686[医药卫生—骨科学]