克拉霉素联合鼻腔局部用药治疗慢性鼻窦炎疗效分析  

Study of Clarithromycin combined with local treatment on chronic nasosinusitis

作　　者：沈伟芳[1] 李玲[1] 

机构地区：[1]同济大学附属第十人民医院药剂科,上海200072

出　　处：《同济大学学报（医学版）》2009年第5期128-130,共3页Journal of Tongji University(Medical Science)

摘　　要：目的观察大环内酯类抗生素新作用及其在慢性鼻窦炎多途径治疗中的应用。方法采用小剂量的克拉霉素片剂治疗30例慢性鼻窦炎患者,0.25 g/片,1片/d,持续12周,同时用生理盐水鼻腔冲洗加局部激素鼻喷剂早晚各1次。以模拟视觉评分对治疗前后疾病程度及控制情况进行评估。结果治疗前模拟视觉评估平均分为(8±1.57),治疗3个月后平均评分为(3±1.16),差异有统计学意义(P<0.01)。结论小剂量长期服用大环内酯类克拉霉素联合鼻腔冲洗加局部鼻喷剂对慢性鼻窦炎具有一定疗效,其治疗机制有待进一步探讨。Objective To elucidate and examine the efficacy of macrolide on chronic nasosinusitis. Methods A total of 30 patients with chronic nasosinusitis were treated with low dosage of Clarithromycin combined with local treatment on chronic nasosinusitis. The usage of Clarithromycin was 0.25 g once a day for 12 weeks. The VAS （visual analogue scale） was used for evaluating the severity of disease as well as the improvement after treatment. Results VAS was （8 ±1.5 ） before treatment, and （3 ±1.16） after 3 months of oral therapy and the difference was statistically significant. Conclusion Long-term application of low dosage oral macrolide Clarithromycin combined with local treatment on chronic nasosinusitis shows efficacy on chronic nasosinusitis, but the immunomodulatory mechanism is still unknown and needs further study.

关 键 词：大环内酯类抗生素 克拉霉素 慢性鼻窦炎 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]