Preparation of novel chiral stationary phase based on click chemistry for ligand exchange chromatography  

作　　者：Chun Mei Fu Hong Yu Shi Guang Sheng Qian Zhang Wan Li 

机构地区：[1]West China School of Pharmacy, Sichuan University, Chengdu 610041, China [2]Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China [3]Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Chinese Chemical Letters》2009年第11期1345-1347,共3页中国化学快报（英文版）

摘　　要：Click chemistry was applied to immobilize L-proline derivative onto azide-modified silica gel to give a novel chiral stationary phase （denoted as click-CSP） for ligand exchange chromatography. The developed protocol combines the benefits of operational simplicity, exceptionally mild conditions and high surface loadings. The enantioselectivity α of some DL-arnino acids on the click- CSP were found to be in the range from 1.13 to 3.46. The chromatographic resolutions of some DL-amino acids and the stability study firmly illustrate the potential of click chemistry for preparation chiral stationary phase for ligand exchange chromatography.Click chemistry was applied to immobilize L-proline derivative onto azide-modified silica gel to give a novel chiral stationary phase （denoted as click-CSP） for ligand exchange chromatography. The developed protocol combines the benefits of operational simplicity, exceptionally mild conditions and high surface loadings. The enantioselectivity α of some DL-arnino acids on the click- CSP were found to be in the range from 1.13 to 3.46. The chromatographic resolutions of some DL-amino acids and the stability study firmly illustrate the potential of click chemistry for preparation chiral stationary phase for ligand exchange chromatography.

关 键 词：Click chemistry Ligand exchange chromatography Chiral stationary phase vL-amino acids 

分 类 号：O629.711[理学—有机化学] O657.72[理学—化学]