参附强心合剂对心衰大鼠心肌AT_1 AT_2-mRNA表达的影响  

Effects of Shenfuqiangxin Heji on Expression of AT_1 AT_2-mRNA in Cardiac Muscle of Chronic Heart Failure Rats

作　　者：陈铁龙[1] 祝光礼[1] 魏丽萍[1] 刘昭[1] 

机构地区：[1]浙江中医药大学附属广兴医院,浙江杭州310007

出　　处：《中华中医药学刊》2009年第11期2429-2431,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：杭州市科技发展计划项目(LX2007)

摘　　要：目的:探讨参附强心合剂对心衰大鼠心室重塑及心肌AngⅡ受体AT1、AT2-mRNA表达的影响。方法:采用腹主动脉缩窄法制做心衰大鼠模型,观察参附强心合剂对左室重量与体重比(LVW/BW)及心肌组织AngⅡ受体AT1、AT2-mRNA表达的影响。结果:参附强心合剂可降低左室重量指数LVW/BW(P<0.01),下调AT1-mRNA表达,上调AT2-mRNA表达(P<0.05)。结论:参附强心合剂能降低左室重量指数LVW/BW,抑制心室肥厚;调节AT1、AT2表达,逆转心衰大鼠心肌重构的分子生物学改变;从而对慢性心衰有防治作用。Objective： To investigate the influence of Shenfuqiangxin heji （SFQXHJ） on myocardial remodeling and the expression of AT1 ,AT2 - mRNA in chronic heart failure （CHF） rats. Methods： Using male adult SD rats made CHF models by coarctation of abdominal aorta（CAA）. To observe the effect of SFQXHJ on the left ventricular weight （LVW） /body weight （BW） ratio （LVW/BW） and the expression of AT1 ,AT2 -mRNA. Results： SFQXHJ could reduced LVW/ BW obviously（P 〈 0.01 ）, decreased the expression of AT1 -mRNA and increased the expression of AT2 -mRNA（ P 〈 O. 05）. Conclusion： SFQXHJ could reverse the changes in molecular biology of myocardial remodeling and inhibit ventric- ular hypertrophy, then could prevent CHF.

关 键 词：参附强心合剂 心力衰竭 左室重量指数(LVW/BW) AT1AT2 

分 类 号：R285.5[医药卫生—中药学]