抑郁症首次发病患者静息态脑功能局部一致性的研究  

Resting state functional magnetic resonance imaging in patients with first-episode depression and control subjects

作　　者：李海军[1] 杨涛[2] 罗春蓉[1] 余红军[1] 程宇琪[2] 徐健[2] 单保慈[4] 徐林 许秀峰[3] 

机构地区：[1]昆明市第一人民医院磁共振室,650032 [2]昆明医学院第一附属医院精神科 [3]昆明医学院第一附属医院风湿免疫科 [4]中国科学院北京高能物理研究所 [5]昆明动物研究所

出　　处：《中华精神科杂志》2009年第4期193-197,共5页Chinese Journal of Psychiatry

基　　金：云南省科技厅昆明医学院联合基金资助项目（2008C005R）

摘　　要：目的利用功能磁共振（fMRI）和局部一致性（regional homogeneity，ReHo）探讨抑郁症首次发病（以下简称首发）患者在静息态脑功能是否存在异常及异常部位。方法对34例符合美国精神疾病诊断与统计手册第4版诊断标准的首发抑郁症患者（抑郁症组）和34名性别、年龄、文化程度匹配的健康志愿者（对照组）进行静息态fMRI扫描。结果抑郁症组静息态脑血氧水平依赖信号的ReHo高于对照组的脑区有左侧额叶眶回、顶下小叶、颞上回，右侧额内侧回、顶下小叶、小脑后叶；低于对照组的脑区有左颞下回、右颞上回和胼胝体、双侧后扣带回（P〈0．005，K≥10）。结论首发抑郁症患者在静息态存在多个脑区功能活动的异常，并可能和抑郁症的病理机制有关。Objective To explore the abnormal brain activity during resting state in first-episode depressive patients with functional magnetic resonance imaging（fMRI） technique and regional homogeneity （ReHo） method. Methods Thirty-four patients with first-episode major depressive disorder and 34 gender-, age-,and education-matched normal controls received resting-state fMRI scans. Resting-state fMRI data were analyzed using the newly published ReHo approach. Results Compared with control subjects, the ReHo of blood oxygen level dependent signal of depressed patients showed increased in left frontal lobe, orbital-frontal gyri, superior frontal gyms, middle frontal gyms, fight ventral frontal gyms and posterior lobe of cerebellum bilateral inferior parietal lobe. On the other hand, decreased ReHo was found in left inferior temporal gyms, right superior temporal gyms and bilateral posterior cingutate （P 〈 0. 005, K≥ 10 ）. Conclusion These results supported the abnormal resting-state brain activity in the early stage of MDD and might be involved in the pathology of MDD.

关 键 词：抑郁症 磁共振成像 静息态 局部一致性 

分 类 号：R686[医药卫生—骨科学]