小儿硬膜外腔内注入布比卡因、利多卡因的药动学研究  

Pharmacokinetics of Lidocaine and Bupivacaine that Injected into the Epidural Cavity of Children During Epidural Anesthesia

作　　者：陈瑶[1] 张培俊[2] 赵刚[1] 刘青青[1] 

机构地区：[1]云南省第一人民医院药剂科,昆明市650032 [2]云南省第一人民医院麻醉科,昆明市650032

出　　处：《中国药房》2009年第32期2521-2522,共2页China Pharmacy

摘　　要：目的:研究小儿硬膜外腔内注入布比卡因及利多卡因的药动学特征,以探讨该麻醉方法的安全性和有效性。方法:30例择期行隐睾、疝气、鞘膜积液高位结扎术的患儿,给予利-布合剂(2%利多卡因5mg.kg-1+0.75%布比卡因1.875mg.kg-1),使用一次性注药于硬膜外腔的麻醉方法。采用高效液相色谱法测定患儿体内布比卡因、利多卡因的血药浓度,用DASver2.0药动学程序处理拟合,计算药动学参数。结果:小儿体内布比卡因、利多卡因的药-时曲线符合二室模型,利多卡因和布比卡因的药动学参数分别为:tmax为27.0、33.0min,t1/2β为43.97、73.52min,Cmax为2.411、1.475mg.L-1,AUC0～∞为144.714、168.541mg.min.L-1。结论:小儿硬膜外腔内给予局麻药剂量是安全、有效的。OBJECTIVE： To study the pharmacokinetics of lidocaine and bupivacaine in children undergoing epidural anesthesia so as to evaluate the safety and efficacy of this anesthetic method. METHODS： A total of 30 children who were expected to undergo surgery for undescended testis, hernia or high ligature for hydrocele were assigned to receive 2% lidocaine （5 mg·L^-1） plus 0.75% bupivacaine（1.875 mg·L^-1）（single epidural dose） by epidural anesthesia. Plasma concentrations of lidocaine and bupivacaine were determined by HPLC. Pharmacokinetics parameters were calculated and fitted by using DAS ver 2.0 pharmacokinetic program. RESULTS： The plasma concentration time curves of lidocaine and bupivaeaine were in line with a two-compartment model. The main pharmacokinetic parameters of lidocaine vs. bupivacaine were as follows： tmax 27.0 vs.33.0 min; t1/2β 43.97 min vs. 73.52 min; Cmax 2.411 mg·L^-1 vs.1.475 mg·L^-1 AUC0-∞ 144.714 mg·min·L^-1 vs. 168.541 mg.min. L^-1. CONCLUSION： The dosages of the local anesthetics injected into the epidural cavity of children are proven to be safe and effective.

关 键 词：布比卡因 利多卡因 药动学 小儿 硬膜外麻醉 

分 类 号：R969.1[医药卫生—药理学]