顶空毛细管气相色谱法同时测定酒石酸布托啡诺中的多种残留溶剂  

Simultaneous Determination of Six Residual Organic Solvents in Butorphanol Tartrate by Capillary Gas Chromatography with Headspace Sampling

作　　者：宋晓光[1] 朱圣亮[1] 李语如[1] 闫占宽 

机构地区：[1]江苏恒瑞医药股份有限公司,江苏连云港222002

出　　处：《中国实验方剂学杂志》2009年第11期23-25,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的：建立了酒石酸布托啡诺中残留有机溶剂甲醇、丙酮、乙醚、二氯甲烷、氯仿、四氢呋喃的分离测定方法。方法：采用顶空毛细管气相色谱法,色谱柱为ZB-1,检测器为FID,水为溶解介质,乙酸乙酯为内标。结果：甲醇、丙酮、乙醚、二氯甲烷、氯仿、四氢呋喃的线性范围分别为1.811-394.6,1.015-389.4,0.130-407.2,0.447-198.3,1.776-100.6,0.341-201.8μg·mL^-1;甲醇、丙酮、乙醚、二氯甲烷、氯仿、四氢呋喃的平均回收率分别为97.2%,98.8%,102.5%,102.3%,100.3%,96.4%;相对标准偏差均不超过5.0%（n=6）。结论：该方法简单、准确、灵敏度高、重复性好,适用于酒石酸布托啡诺中的有机溶剂残留量的测定。Objective：To develop a headspace gas chromatography method for the residual organic solvents in butorphanol tartrate. Methods： The sample was injected into ZB-1 capillary column by headspace sampler and analysed with FID detector using ethylacetate as the internal standard and H20 as the solvent. Results： Methanol, acetone, dichloromethane, ether, chloroform, tetrahydrofuran were linear at the ranges of 1.811 -394.6μg·mL^-1, 1.015 - 389.41,0.130 - 407.2, 0.447 - 198.3.776 - 100.6, 0.341 - 201.8 μg·mL^-1, respectively; The recoveries were 97.2%, 98.8%, 102.5%, 102.3%, 100.3%, 96.4% respectively. Each of the relative standard deviations was no more than 5.0%. Conclusion： The method is simple, accurate and sensitive with good reproducibility. It can be used for the determination of the residual organic solvents in butorphanol tartrate.

关 键 词：酒石酸布托啡诺 顶空进样 毛细管气相色谱法 残留溶剂测定 

分 类 号：R284.1[医药卫生—中药学]