西藏芫根提取物对小鼠抗缺氧作用的初步研究  

Primary Study on Anti-hypoxia Activity of Bassia rapa L. Extract in Mice

作　　者：谢玥[1] 马超 蒋思萍 陈志娟[1] 张闻杰[1] 苏东海[1] 皮宁宁[1] 苏文涛[1] 钱俊伟[1] 卜海涛 高平[1] 

机构地区：[1]四川大学生命科学学院,成都610064 [2]西藏自治区高原生物研究所

出　　处：《四川动物》2009年第6期853-856,共4页Sichuan Journal of Zoology

基　　金：西藏自治区科技厅重点项目(2005016)

摘　　要：实验研究西藏芫根提取物的抗缺氧活性。通过建立小鼠常压缺氧模型、急性脑缺血性缺氧模型以及亚硝酸钠中毒模型,以蒸馏水作为空白对照,盐酸普萘洛尔作为阳性对照,观察芫根水、65%乙醇及95%乙醇提取物的10g/kg、15g/kg和20g/kg剂量组对小鼠缺氧的保护作用,同时观察各提取物10g/kg剂量组对红细胞数量和血红蛋白含量的影响。结果表明,芫根水提取物、65%乙醇提取物及95%乙醇提取物均能明显延长模型小鼠在常压缺氧、急性脑缺血性缺氧及亚硝酸钠中毒时的存活时间,并可增加外周血象中红细胞数与血红蛋白含量,显示芫根提取物具有抗缺氧活性。The effect of Bassia rapa L. extract on anti-hypoxia was investigated. Using distilled water as a blank control and propranolol hydrochloride as a positive control, the survival time of mice in hypoxia under ordinal＇ pressures, and with acute cerebral ischemia and sodium nitrite were used to evaluate the anti-hypoxic effect of three different doses （ 10, 15, 20 g/kg） of 65%, 95% alcohol extract and water extract of Bassia rapa L. Erythrocyte number and hemoglobin count were used to investigate the anti-hypoxic effect of 65% , 95% alcohol extract and water extract （ 10 g/kg） of Bassia rapa L. The result indicates that Bassia rapa L. 65%, 95% alcohol extract and water extract can prolong the survival time of mice in hypoxia under ordinary pressures significantly. It can also prolong the survival time of mice with acute cerebral ischemia and sodium nitrite significantly, and increase the number of erythrocytes and the content of hemoglobin. It demonstrates that Bassia rapa L. extract has anti-hypoxia activity.

关 键 词：西藏芫根 抗缺氧 小鼠 

分 类 号：R285.5[医药卫生—中药学]