石榴籽油对高脂膳食大鼠血脂的影响  

Effect of Seed oil of Punica gramatum L. on blood-lipid in hyperlipidemia rats

作　　者：李雪梅[1] 张颖[1] 王枫[2] 

机构地区：[1]陕西省疾病预防控制中心,710054 [2]第四军医大学营养与食品卫生学教研室

出　　处：《公共卫生与预防医学》2009年第5期39-41,共3页Journal of Public Health and Preventive Medicine

摘　　要：目的研究石榴籽油对高脂膳食大鼠血脂水平的影响。方法50只雄性SD大鼠按体重随机分为5组:空白对照组(C)、高脂模型组(HFC)、高脂低石榴籽油组(HFLP)、高脂中石榴籽油组(HFMP)、高脂高石榴籽油组(HFHP),除空白对照组饲以普通饲料外,其余各组饲以高脂饲料并用不同剂量石榴籽油进行干预。结果4周后,血清TC、TG、LDL-C、AI等指标,高脂模型组均显著高于空白对照组(P<0.05或P<0.01),HDL-C(P<0.05或P<0.01)下降;石榴籽油干预组血清TC、TG、LDL-C、AI等指标均显著低于高脂模型组(P<0.05或P<0.01),而HDL-C升高(P<0.05或P<0.01)。结论石榴籽油可显著抑制高脂膳食大鼠血脂的增高。Objective To study the effect of Seed Oil of Punica gramatum L. on Blood-lipid in Hyperlipidemia Rats. Methods Fifty male SD rats were randomly devided into 5 groups by body weight ： control group, high fat diets model group,high fat diets with seed oil of Punica gramatum L high,middle and low dose. Results Mter four weeks,the level of serum total cholesterol（ TC ）, triglyceride （TG） ,low-density lipoprotein cholesterol（LDL-C） and arteriosclerosis index （AI） of high-fat diet model group were all higher than the control group（ P 〈 0.05 or P 〈 0.01 ）, while high density lipoprotein （HDL-C） level was lower than the control group （P 〈 0.＇05 or P 〈 0.01 ）. The content of serum total cholesterol （TC）, triglyceride （ TG）, low-density lipoprotein cholesterol （LDL-C） and arteriosclerosis index （AI） in Punica gramatum L. seed oil group were all lower than that of the high-fat diet group （ P 〈 O. 05 or P 〈 0. O! ）. While the high-density lipoprotein cholesterol（HDL-C） were higher than that of the control control group （P 〈 0. 05 or P 〈 0.01 ）. Conclusions Seed oil of Punica gramatum L. has significant inhibiting effect on the increase of serum lipids level in high-fat diets rats.

关 键 词：石榴籽油 高脂膳食 血脂 脂蛋白 高脂血症 

分 类 号：R54[医药卫生—心血管疾病]