重症肺炎患儿万古霉素血药浓度监测结果分析  

Analysis of results of serum concentration of Vancomycin in severe case of pneumonia in children

作　　者：许琼[1] 汪洋[1] 梅艳[1] 陈渝军[1] 宋新文[1] 

机构地区：[1]武汉市儿童医院,湖北武汉430016

出　　处：《中国医药导报》2009年第32期15-16,共2页China Medical Herald

摘　　要：目的:通过分析30例重症肺炎患儿万古霉素血药浓度的监测结果,探讨万古霉素治疗药物监测的必要性、在重症肺炎患儿体内代谢的个体差异及影响因素。方法:采用高效液相色谱法测定30例重症肺炎患儿使用万古霉素后的血药浓度值,将浓度值、性别、年龄、身高、体重、生化指标等资料录入数据库,进行统计学分析。结果:30例患儿的万古霉素血药峰浓度和谷浓度在治疗窗范围内分别只占6.67%和16.67%,血药浓度普遍偏低;血药峰浓度和谷浓度与给药剂量无显著相关(r=0.185,P=0.328;r=0.147,P=0.438);单位剂量血药浓度值与年龄、身高、体重及各项生化指标均无显著相关(P>0.05)。结论:万古霉素在重症肺炎患儿体内的代谢个体差异显著,其影响因素复杂且不确定,应根据血药浓度监测结果制订和调整给药方案。Objective： To investigate the essentiality of Vancomycin therapeutic drug monitoring and individual difference of metabolism of Vancomycin in severe case of pneumonia in children and its influential factors through analyzing the results of serum concentration of Vancomycin in 30 severe cases of pneumonia. Methods： The serum concentration of Vancomycin in 30 severe cases of pneumonia was determined by HPLC, and recorded the concentration, sexuality, age, height, weight and biochemical indicator into database, then the data were analyzed. Results： The rate of peak concentration and valley concentration of Vancomycin in therapeutic window in 30 cases were 6.67% and 16.67% respectively. The serum concentrations of Vancomycin were low in 30 cases, and there was no significant relation between the serum concentration and the medicine dosage （r=0.185, P=0.328; r=0.147, P=0.438）. There was no significant relation between the serum con centration and the age, height, weight and biochemical indicator （P〉0.05）. Conclusion： There are significant individual dif- ferences in metabolism of Vancomycin in severe case of pneumonia in children, and we do not find out its influential factor. We should formulate and modulate the dose schedule through the result of serum concentration.

关 键 词：重症肺炎 儿童 万古霉素 血药浓度 影响因素 

分 类 号：R96[医药卫生—药理学]