大白鼠抑郁症模型的MRI方法研究  

INVESTIGATION OF THE DEPRESSED RAT MODEL BY MRI

作　　者：卢广[1] 胡红兵[1] 丁广良[1] 李丽云[1] 叶朝辉[1] 王雪琦[2] 路长林[2] 

机构地区：[1]中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室 [2]中国人民解放军第二军医大学

出　　处：《波谱学杂志》1998年第4期303-306,共4页Chinese Journal of Magnetic Resonance

基　　金：中国科学院基础性重大项目

摘　　要：用核磁共振成象方法研究对比了抑郁症大白鼠与对照组正常大白鼠脑部的核磁共振信号强度的差别．从大白鼠大脑的核磁共振图象出发，经过数据分析，发现抑郁症大白鼠多个脑组织的核磁共振信号相对强度普遍比正常大白鼠高．另外，模型组大白鼠大脑的脑裂比对照组大白鼠的脑裂更深且更宽．The differences in nuclear magnetic resonance signal intensity of rat brain between normal rats of controlling group and depressed rats of model group have been investigated using the approach of magnetic resonance imaging (MRI). Based in the MRI images and the data analysis, it was generally found that the NMR signal from various cerebral tissues of the depressed rats were more intense than those of controlled rats. On the other hand, the images suggested that the fissures of the depressed rats cerebrum were deeper and broader than those of normal rats.

关 键 词：核磁共振成象 大白鼠 抑郁症 MRI 脑裂比 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]