卡培他滨与放射联合对子宫颈腺癌抗肿瘤效果的实验研究  

Anticancer Efficacy of Concurrent Capecitabine and Radiation Therapy for Cervical Adenocarcinoma in Nude Mice

作　　者：杨滨[1] 阎华 王欣彦[1] 李东博[3] 佐々木宽 尚涛[1] 赵玉芬[5] 

机构地区：[1]中国医科大学附属盛京医院妇产科,沈阳110004 [2]辽宁省计划生育科研院附属医院妇科,沈阳110031 [3]中国医科大学附属盛京医院药剂科,沈阳110004 [4]日本东京慈惠会医科大学附属病院妇产科 [5]沈阳市康平县人民医院妇产科,辽宁康平110500

出　　处：《中国医科大学学报》2009年第10期751-754,共4页Journal of China Medical University

摘　　要：目的探讨卡培他滨(CAP)与放射联合对子宫颈腺癌裸鼠移植瘤的抑制效果。方法将接种CAC-1细胞的裸鼠随机分成对照组、CAP组、5-氟尿嘧啶(5-FU)组、放射组、CAP+放射组、5-FU+放射组,并设肿瘤大小不同的两大组,将大、小瘤组又分出对照组、CAP组、放射组、CAP+放射组。观察肿瘤体积变化,计算增殖百分率,推算肿瘤生长延迟时间。结果2/3MTDCAP+放射(6Gy、2Gy/d×8次)联合治疗组与对照组、单纯药物组及单纯放射组相比,联合治疗效果显著(P<0.05),明显强于2/3MTD5-FU+6Gy的抑制效果,其中CAP+2Gy/d×8次的疗效最为突出;大瘤组肿瘤对联合治疗效果明显(P﹤0.05),小瘤组肿瘤对联合治疗反应性差。结论CAP与放射联合应用对子宫颈腺癌CAC-1裸鼠移植瘤有明显抑制效果,两者之间具有协同作用,并受放射剂量、放射方式影响,也可能受肿瘤大小影响。Objective To observe the therapeutic effect of the new plan of concurrent capecitabine （CAP） and radiation therapy for human cervical adenocarcinoma in nude mice. Methods The nude mice were injected with CAC-1 cells for the modelization of cervical adenocarcinoma. Before treatment,all mice with tumors were randomly divided into control group,CAP group,5-FU pup,radiation group,CAP＋ radiation group, 5-FU＋radiation group. According to the tumor size, mice were fmtherly divided into large-size and small-size groups in the control group, CAP group, radiation group, CAP＋radiation group. The change of tumor size, tumor growth percentage and the delay time of tumor growth were evaluated. Results The therapeutic effect of combining 2/3MTD CAP with 6 Gy radiation or fractionation 2 Gy × 8 times radiation was better than that of the control group, chemotherapy group and the radiation group. The difference was significant （P 〈 0.05）. The restraint effect of the combining 2/3MTD CAP with 6 Gy radiotherapy was better than that of the combining 2/3MTD 5-FU with 6 Gy radiotherapy. Combining 2/3MTD CAP with fractionation 2 Gyx8 times radiation therapy was more efficient than Combining 2/3MTD CAP with fractionation 6 Gy radiation therapy. In combining therapy groups, the response of large-size tmnors was more significant than that of the small-size tumors （P〈 0.05）,which had almost no obvious response. Conclusion Concurrent CAP and radiation therapy has obvious restraint effect on CAC-1 cervix adenocarcinoma in nude mice. The CAP and radiation therapy can promote the therapeutic effect to each other. The therapeaufic effect of the concurrent CAP and radiation therapy is affected by the radiation dose, radiation method and the tumor size.

关 键 词：卡培他滨 放射线 子宫颈腺癌 裸鼠 

分 类 号：R711.74[医药卫生—妇产科学]