糖尿病足感染细菌谱和药敏分析  

Analysis of specimens and antimicrobial susceptibilities of the bacteria isolated from diabetic foot

作　　者：陆雷群[1] 陈玲[1] 郁忠勤[1] 王宇森[1] LU Leiqun, CHEN Ling ,YU Zhongqing, WANG Yusen. （Ruijin Hospital Luwan Branch ,Shanghai200025 ,China ）

机构地区：[1]上海市瑞金医院卢湾分院,200025

出　　处：《社区卫生保健》2009年第5期354-355,366,共3页Journal of Community Healthcare

摘　　要：目的探讨糖尿病足感染病原菌的特点及其耐药性。方法回顾性分析2004年1月～2009年6月从60例糖尿病足病人标本中分离的细菌特点及其耐药性。结果糖尿病足感染标本中检出的细菌革兰氏阳性（G＋）球菌占48．05％，革兰氏阴性菌（G-）占45．45％，真菌占6．49％，其中10例为混合菌感染。被检出的G＋球菌株对万古霉素和利奈唑胺敏感，G-杆菌菌株对亚胺培南、头孢哌酮／舒巴坦、阿米卡星敏感。结论本研究对于糖尿病足感染合理选用抗生素仅供临床参考，由于菌种多变、耐药菌株不断产生，故及时对病原菌及其耐药性监测是非常必要的，选择合理有效抗生素，减少耐药株的产生，提高治愈率。Objective To explore spectrum and antimicrobial resistance of the bacteria isolated from infec tious diabetic foot. Method To collect 60 patients suffered from diabetic foot infection hospitalized in our endocrine department from January 2004 to June 2009 ,bacteria culture and its＇ antimicrobial susceptibility were taken. Results Gram-positive Cocci occupied 48.05% ,the prevalence were Staphylococcus aureus, Staphylococcus epidermides, Staphylococcus haemolyticus in turn these G- strains were susceptible to Vancomycin, Linezolid. Gram-negative bacilli occupied 45.45%, the prevalence were Pseudomonas acrogenous. Escherichia Coli Enterobacter aerogenes in turn. These G-bacilli strains were susceptible to Imipenem, Cefoperazone/Sulbactam and Amikacin. Fungi occupied 6.49 %. There were 10 cases multipathogens infection, it led worse prognosis. Conclusion Our study only rends a reference for the treatment of diabetic foot, but the bacteria specimens and its＇ antimicrobial resistance vary in different hospitals, so bacteria culture and antimicrobial resistance should be performed in time for the guiding rational antimicrobial therapy.

关 键 词：糖尿病足 感染 病原菌 耐药性 

分 类 号：R56[医药卫生—呼吸系统;医药卫生—临床医学;医药卫生—内科学] R587.2[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]