AANAT-褪黑素-松果腺在中医五脏调控理论中的作用  

AANAT-melatonin-pineal gland in TCM regulation theory of five zang-viscera

作　　者：许筱颖[1] 郭霞珍[1] 刘晓燕[1] 刘品祥[1] 林英豪[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《北京中医药大学学报》2009年第10期657-658,662,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.30472113)

摘　　要：通过对褪黑素合成限速酶-褪黑素-松果腺与中医五脏调控理论关系的分析,结合前期研究成果认为:松果腺是五脏调控与五季关系的中介;褪黑素可能是中医学五脏与五时相通应的主要调节点;芳基烷化胺N-乙酰转移酶(AANAT)作为褪黑素合成的主要限速酶,其活性的季节性变化决定了褪黑素合成的速率和节奏,对褪黑素的浓度起着关键性作用。最后提出褪黑素合成限速酶-褪黑素-松果腺是中医五脏调控理论研究最合适的切入点。Combined the achievemetns of prophase researches, it was thought that, based on the analysis on the relationship between aryl-alkylated amine N-acetyltransferase （AANAT）-melatonin-pineal gland and TCM regulation theory of five zang-viscera, pineal gland was a medium in the relation between five zang-viscera regulation and five seasons, and melatonin might be a set point in the correspondence between five zang-viscera and five seasons. AANAT, as a main rate-limiting enzyme of melatonin synthesis, had seasonal changes in its activity, which determined the rate and rhythm of melatonin synthesis and played a very important role in melatonin concentration. AANAT-melatonin-pineal gland was thought as the breakthrough point in the research of TCM regulation theory of five zang-viscera.

关 键 词：褪黑素合成限速酶 褪黑素 松果腺 五脏调控 作用 

分 类 号：R2-3[医药卫生—中医学]