辛热类中药诱导大鼠阴虚状态的实验研究  

Experimental study on the rat’s yin deficiency situation induced by pungent and hot Chinese Herbs

作　　者：赖永金[1] 张冰[1] 刘小青[1] 金勇男[1] 李敏[1] 

机构地区：[1]北京中医药大学中药学院,北京100029

出　　处：《中华中医药杂志》2009年第11期1440-1442,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点基础研究发展计划(973计划)项目(No.2007CB512605)

摘　　要：目的:观察辛热类中药诱导大鼠阴虚状态的稳定性和基本病理变化。方法:100只SD雄性大鼠随机分成正常组、阴虚组,每组50只,在实验9、12、14、16、18d每组分别取10只动物取血,检测第二信使cAMP、cGMP、内分泌系统、物质代谢、肛温等相关指标。结果:与正常组比,阴虚组大鼠给药12d到16d:肛温、cAMP、T3、T4明显升高;TC、TG明显降低(P<0.05)。COR、E2、GLU有升高趋势。结论:本实验大鼠阴虚状态稳定持续时间为给药12d到16d,阴虚的基本病理改变可能与细胞内cAMP浓度升高、内分泌功能紊乱、机体物质代谢增强密切相关。Objective： To study the stability and fundamental pathology of the rat＇s yin situation induced by pungent and hot Chinese herbs. Methods： One hundred SD rats were randomly divided into to groups （normal group, n=50; yin deficiency group, n=50）. The second messenger （cAMP and cGMP）, immune system, substance metabolism, rectal temperature and so on were detected on 9th, 12th, 14th, 16th and 18th day. Results： From 12th day to 16th day, compared with the normal group： the yin deficiency group animals had dramatic increase in rectal temperature, the level of cAMP, T3,T4 ane dramatic fall in TC,TG（P〈0.05）, which also had an increase tendency in COR, E2, GLU. Conclusion： The current study indicated that the rat＇s yin deficiency induced by pungent and hot Chinese herbs was stable from 12th day to 16th day. The basic pathological appearances of yin deficiency were related to increase of intracellular cAMP, the endocrine abnormalities, and the enhancement of substance metabolism.

关 键 词：辛热类中药 阴虚 实验研究 

分 类 号：R285.5[医药卫生—中药学]