股骨头坏死修复过程中断的原因分析  

Analysis on reparative process interruption of femoral head necrosis

作　　者：崔永锋[1] 王利明[2] 肖鲁伟[2] 童培建[2] 

机构地区：[1]杭州市萧山区第一人民医院,杭州311201 [2]浙江中医药大学第一临床医学院,杭州310053

出　　处：《中华中医药杂志》2009年第11期1473-1476,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中国博士后科学基金资助项目(No.20080431334)

摘　　要：股骨头坏死(ONFH)临床疗效不佳的原因主要是股骨头硬化带的形成导致修复过程的中断,药物作用难以到达坏死中心。但目前对硬化带形成机制的研究甚少,修复过程中断的原因不明。文章根据大量病理切片和文献资料的研究,对股骨头坏死硬化带的形成机制及修复过程中断的原因提出了资源竞争、应力损害、神经失调和血管淤阻这4种假说,从不同侧面分析推理了硬化带修复不完全而长期存在的内在机制。这4种假说为研究股骨头坏死修复过程中断的原因,提供一种新的思路。The key reason for reparative process interruption of femoral head necrosis is the formation of hardening layer, which make it hard for medicine to act on the necrosis center. The research on formation mechanism of hardening layer is limited and the reason for reparative process interruption is unknown. Based on lots of pathological section and literature data, four hypotheses about the reason for reparative process interruption are proposed, including resource competition, damage of stress, disturbance of nerves and stasis of blood vessel. The internal mechanism of incomplete reparation and chronicity of hardening layer was analyze from different aspects. The four hypotheses provides a new thinking for study the reason for reparative process interruption.

关 键 词：股骨头坏死 资源竞争 应力损害 神经失调 血管淤阻 硬化带 假说 

分 类 号：R681.8[医药卫生—骨科学] R318[医药卫生—外科学]