参附注射液治疗轻度椎-基底动脉狭窄性眩晕的临床研究  

Clinical research on effect of Shenfu Injection in treating vertigo of mild vertebrobasilar stenosis

作　　者：田作军[1] 张志敏[1] 杨志华[1] 刘磊[1] 

机构地区：[1]广州医学院第一附属医院,广州510120

出　　处：《中华中医药杂志》2009年第11期1493-1496,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广州医学院博士启动基金(No.广医发[2006]181号)

摘　　要：目的:评价参附注射液治疗轻度椎-基底动脉狭窄性眩晕的效果。方法:将2005年1月-2008年7月以眩晕为首发症状,经DSA检查按NASCET标准诊断轻度椎-基底动脉狭窄(MVS)的患者66例,随机分为参附组(SF组)34例和丹参对照组(DS组)32例。以眩晕障碍量表的筛查表(DHI-S)和眩晕评定量表的评分系统(DARS)来评定患者在刚入院、治疗的第3d、第6d及出院时的眩晕程度,并在患者入院及出院时2次检测其左、右椎动脉及基底动脉的平均血流速度(Vm)、阻力指数(RI)、血清红细胞比容(Hmc)和纤维蛋白原(Fbg)的水平。结果:入院时SF组和DS组的眩晕评分、TCD及血清学指标均无统计学意义;在治疗的第6d和出院时,SF组DHI-S和DARS评分均低于DS组(P<0.01及P<0.05);治疗后SF组左、右椎动脉及基底动脉的Vm均高于DS组(P<0.05)、RI均低于DS组(P<0.05),血清Hmc及Fbg均低于DS组(P<0.05)。结论:参附注射液能有效改善血液流变性和血液黏度缓解MVS的眩晕症状。Objective： To evaluate the effect of Shenfu Injection in treating vertigo of mild vertebrobasilar stenosis. Methods： From January 2005 to July 2008, 66 patients with the primary symptom of vertigo undergoing digital subtraction angiograpby （DSA） examination were diagnosed as mild vertebrobasilar stenosis （MVS） according to the North American symptomatic carotid endarterectomy trial （NASCET） criteria, and then randomly divided into Shenfu （SF） group （34 cases） and Danshen （DS） group （32 cases）, the DS group acting as the control. Degrees of vertigo of the patients were evaluated by the screening version of the dizziness handicap inventory （DHI-S） and scoring system for the dizziness assessment rating scale （DARS） on the admitted day, the third and sixth day after treatment and discharged day respectively. The mean of blood flow velocity （Vm）, resistance index （RI） of right and left vertebral arterys and basilar artery, hematocrit （Hmc） and fibrinogen （Fbg） level in serum were all examined on both the admitted and discharged days. Results： There was no significant difference on the score of vertigo, the parameter of TCD and the index in serum between SF and DS groups at the admitted time. On the sixth day of treatment and the discharged day, the score of DHI-S and DARS in SF group were lower than those in DS group （P〈0.01 and P〈0.05, respectively）. After treatment the Vms of right and left vertebral artery and basilar artery in SF group were higher than those in DS group （P〈0.05）, and the RIs in SF group lower than those in DS group （P〈0.05）, the Hmc and Fbg in serum in SF group also lower than those in DS group （P〈0.05）. Conclusion： Shenfu injection can effectively improve the blood rheological characteristic and blood viscosity and further relieve the vertigo symptoms of MVS.

关 键 词：椎-基底动脉狭窄 参附注射液 眩晕 

分 类 号：R277.7[医药卫生—中医学]