母婴配对及小月龄婴儿风疹母传抗体消长研究  

Change of Rubella Antibody Transferred by Mother in Infants

作　　者：马瑞[1] 许国章[1] 马超[2] 安志杰[2] 徐宏杰[3] 马衍辉[4] 边国林[1] 董红军[1] 李岩[3] 胡风霞[4] 周绍英[1] 梁英[3] 刘岚铮[4] 怀清杰[3] 韩秀云[4] 倪红霞[1] 李黎[2] 

机构地区：[1]宁波市疾病预防控制中心,浙江宁波315010 [2]中国疾病预防控制中心免疫规划中心,北京100050 [3]哈尔滨市疾病预防控制中心,黑龙江哈尔滨150010 [4]济南市疾病预防控制中心,山东济南250013

出　　处：《中国疫苗和免疫》2009年第5期429-431,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解小月龄婴儿风疹抗体水平及母婴风疹抗体的关系,为制订风疹减毒活疫苗(Rubella Attenuated Live Vaccine,RubV)免疫策略及预防控制先天性风疹综合征提供依据。方法在浙江省宁波市、山东省济南市、黑龙江省哈尔滨市,选取0、3、6、8、9月龄未患过风疹的本地常住婴儿及母亲作为研究对象,采用酶联免疫吸附试验检测风疹IgG抗体。结果0、3、6、8、9月龄婴儿风疹抗体阳性率分别为74.4%、14.9%、3.3%、4.6%、15.0%,几何平均浓度(Geometric Mean Concentration,GMC)分别为34.06、5.42、1.48、1.10、1.83IU/ml(国际单位/亳升),母亲的抗体阳性率为71.1%,GMC为30.96IU/ml;母婴风疹抗体的相关系数为0.658。结论婴儿风疹母传抗体随月龄增长而下降,6、8月龄婴儿风疹抗体几乎无保护作用。Objective To Know the antibody level of comparison in maternal-infant pairs and the change of rubella in infants, and to provide scientific basis for controlling congenital rubella syndrome. Methods Newborn, 3, 6, 8, 9-month infant who never had rubella and their mothers were residents in Ningbo of Zhejiang, Harbin of Heilongjiang and Jinan of Shandong were collected as objects. Their serum samples were tested by the method of ELISA. Results The positive rate of Rubella antibody in newborns, 3, 6, 8, 9, were 74.4, 14.9, 3.3, 4.6, 15.0 percent respectively, and GMC were 34.06, 5.42, 1.48, 1.10, 1.83IU/ml respectively. The positive rate and GMC of Rubella antibody in mothers were 71.1 percent and 30.96IU/ml. The correlation coefficient between mother and infant was 0.658. Conclusion Maternal-transferred rubella antibody decreased as the growth of infants. The positive rate of measles antibody was very low in 6 and 8-month, which almost had no protection.

关 键 词：风疹 母传抗体 婴儿 免疫策略 

分 类 号：R511.2[医药卫生—内科学] R186[医药卫生—临床医学]