仙灵骨葆联合保妇康栓防治绝经后女性泌尿生殖系统感染的临床研究  

Clinical research of preventing and treatment postmenopausal infection of urogenital system by Xianlinggubao capsules combined with Baofukang suppository

作　　者：王雅琴[1] 郭侠[2] 金翠香[3] 耿昭[4] 

机构地区：[1]山东大学南区医院妇科,250061 [2]山东大学南区医院检验科 [3]山东大学南区医院内科 [4]山东大学医学院

出　　处：《中国妇幼保健》2009年第32期4562-4565,共4页Maternal and Child Health Care of China

基　　金：山东省自然科学基金资助项目[Y2006C40]

摘　　要：目的:探讨仙灵骨葆联合保妇康栓防治绝经后女性泌尿生殖系统感染的临床效果及可行性。方法:选择山东大学南区医院2005年9月～2007年6月的绝经后再发性泌尿生殖系统感染患者66例,随机分为3组:观察组(A组,22例)口服仙灵骨葆、阴道用保妇康栓;阳性对照组(B组,22例)口服尼尔雌醇,阴道用保妇康栓;空白对照组(C组,22例)单独阴道用保妇康栓。3组患者均据药敏试验给予有效抗生素,确诊泌尿系感染近期治愈后随访半年,观察泌尿系感染再发情况、药物不良反应及患者的依从性;监测血清雌二醇(E2)水平、阴道脱落细胞成熟指数(MI)、阴道健康评分及宫颈脱落细胞TBS分级等指标。结果:观察组用药后血清E2水平升高,可达到早卵泡期水平(P<0.05)、阴道评分等监测指标也明显改善(P<0.05),泌尿系感染再发率低,药物不良反应少,患者依从性好。结论:仙灵骨葆联合保妇康栓可有效防治绝经妇女性泌尿生殖系统感染,与激素替代疗法(HRT)效果相当,不良反应少,可行性好。Objective：To research the clinical efficiency and feasibility of preventing and treatment postmenopausal infection of urogenital system by Xianlinggubao capsules combined with Baofukang suppository.Methods：From September 2005 to June 2007,66 cases of patients with postmenopausal genitourinary tract infections were divided randomly into 3 groups：observation group（group A,22 cases）,positive control group（group B,22 cases） and blank control group（group C,22 cases）.The patients in group A took Xianlinggubao capsules orally and used Baofukang suppository in vagina,the patients in group B took Nilestriol tablet orally and used Baofukang suppository in vagina and group C used Baofukang suppository in vagina only.All patients of 3 groups took effective antibiotics according to drug sensitivity test.All patients were followed up 6 months.During this period,the infection recurrence,adverse drug reaction and patient compliance were observed;the serum estradiol（E2） level,vaginal exfoliate cell maturation index（MI）,vagina health score,cervical exfoliated cells TBS classification was monitored.Results：The serum E2 of group A was elevated to the level of early follicular phase and present lower rate of urogenital system infection,less adverse drug reaction and better compliance.Conclusion：Xianlinggubao capsules combined with Baofukang suppository can effectively prevent postmenopausal recurrent infection of urogenital system.It has a same efficacy as hormone replacement therapy（HRT）,but with less side effect,and has good feasibility.

关 键 词：绝经后 泌尿生殖道感染 植物雌激素 激素替代疗法 

分 类 号：R691.3[医药卫生—泌尿科学]