错误相关负波(ERN)在精神病理学研究中的应用  

Application of Error-Related Negativity (ERN) in Psychopathological Research

作　　者：张华[1] 刘春雷[1] 王一峰[1] 张庆林[1] 

机构地区：[1]西南大学心理学院,重庆400715

出　　处：《心理科学进展》2009年第6期1211-1219,共9页Advances in Psychological Science

基　　金：西南大学国家重点学科"基础心理学"资助项目(西国重NSKD06002)

摘　　要：错误相关负波(error-related negativity,ERN)是由行为错误诱发的一种脑电波成分,最大峰值在错误反应之后的50ms左右,偶极子源定位于前扣带回(anterior cingulate cortex,ACC)附近。错误加工(error processing)的经典研究范式中出现的ERN成分可能反映了ACC具有错误检测、冲突监控、强化学习、情绪动机等功能。大量研究表明过度的和不足的错误相关脑活动(hyperactive and hypoactive error processing)可能分别与精神病理学的内化性和外化性障碍(internalizing and externalizing disorders)相关联。内化性和外化性障碍的内表型(endophenotype)的研究,还存在许多值得进一步探索的问题。The ERN is a negative deflection in the event-related potentials that peak approximately 50 ms after the commission of an error; it＇s located around anterior cingulate cortex （ACC）. The ERN in classical paradigms of error processing research may reflect error detecting, conflict monitoring, reinforcement learning, or motivational/affective functions of ACC. A Lot of researches suggests that increased and decreased error-related brain activities are associated with the internalizing and externalizing dimensions of psychopathology, respectively. There are many issues worthy of further exploration in terms of the endophenotype construct of internalizing and externalizing disorders.

关 键 词：错误加工 ERN 精神疾病 精神病理学 内表型 

分 类 号：B845[哲学宗教—心理学]