Ⅱ型肝素诱导的血小板减少并血栓形成综合征1例及文献复习  

Heparin-induced thrombocytopenia and thrombosis syndrome:a case report and review

作　　者：王春颖[1] 王京华[1] 谢蕊[1] 孙占峰[2] 鞠威[1] 车德海[1] 贾瑞春[1] 

机构地区：[1]哈尔滨医科大学附属第二医院血液内科,哈尔滨150086 [2]哈尔滨医科大学附属第二医院血管外科

出　　处：《临床血液学杂志》2009年第6期588-591,共4页Journal of Clinical Hematology

基　　金：黑龙江省科技攻关项目(No:GC05C40501)

摘　　要：目的:提高对肝素诱导的血小板减少并血栓形成综合征(HITTS)的认识水平,探讨肝素诱导的血小板减少症(HIT)的实验室诊断体系。方法:报告1例HITTS患者的临床表现及实验室检查。结果:患者血小板计数减少,HIT抗体ELISA检测、肝素诱导的血小板聚集试验(HIPA)、流式细胞仪检测血小板微粒(FCM)均阳性。结论:该例明确诊断为HITTS。监测血小板计数、HIT抗体、HIPA、FCM并结合临床表现可以很好地诊断HITTS。Objective：To improve the recognition of heparin-induced thrombocytopenia with thrombosis syndrome（HITTS）,and to develop the laboratory diagnosis of heparin-induced thrombocytopenia（HIT）.Method：Detailed clinical manifestation of a patient with HITTS was presented.A series of laboratory examinations were performed.Result：The patient＇s platelet count decreased.Antibodies against heparin and platelet factor 4 complexes（antibodies of HIT） were detected by enzyme-linked immunosorbent assay（ELISA）,heparin induced platelet activation（HIPA） test and by examing platelet microparticles using flow cytometry（FCM）.Conclusion：The final diagnosis of the patient is HITTS.HITTS can be diagnosed by monitoring platelet count and detecting antibodies of HIT with ELISA,HIPA and FCM wtih analyzing clinical manifestation.

关 键 词：肝素 血小板减少 血栓形成 实验室诊断 

分 类 号：R558[医药卫生—血液循环系统疾病]