超声微泡对大鼠前列腺中药物浓度的影响  

Experimental study on the influence of ultrasound-mediated microbubble on the medicine concentration in rat prostate

作　　者：魏武然[1] 张唯力[1] 戴君勇[1] 刘颖[1] 王志刚[2] 冉海涛[2] 

机构地区：[1]重庆医科大学附属第二医院泌尿外科,重庆400010 [2]重庆医科大学超声影像学研究所,重庆400010

出　　处：《重庆医科大学学报》2009年第9期1154-1156,共3页Journal of Chongqing Medical University

基　　金：国家自然科学基金重点项目资助(30430230)

摘　　要：目的:利用超声白蛋白微泡造影剂经一定声压超声辐照后产生的"声孔效应"(Sonoporation),以及其靶向性来提高前列腺内的药物浓度。方法:选取已建立慢性前列腺炎模型大鼠30只,随机分为对照组,给药组和给药加微泡组。将EA-10原料药以溶媒溶解后注射给药。对照组给予生理盐水,给药组以15mg/kg剂量给药,微泡组以15mg/kg剂量给药,给药后微泡尾静脉注射并用超声基因转染仪前列腺局部间歇辐照2min。照射后取前列腺组织,匀浆后测量组织中EA-10的浓度变化。结果:对照组前列腺组织中没有药物,给药组和给药加微泡组前列腺组织中药物浓度较对照组高(P<0.01),给药加微泡组前列腺组织中药物浓度较给药组高(P<0.05)。结论:超声白蛋白微泡造影剂的"声孔效应"对于前列腺组织药物浓度的提高有明显的促进作用。Objective：To increase the medicine concentration in rat prostate by the ＂sound aperture effect＂ and site-targeted effect of ultrasound-Mediated Microbubble in order to get better therapeutic effect. Methods： 30 1-year-old male Sprague-Dawley rats were castrated and injected estradiol benzoate for 30 days and divided into three groups randomly, model group, treatment group and ultrasound-mediated microbubble group. Model group was treated with sodium chloride, treatment group was treated with EA-10 and ultrasound-mediated microbubble group was given ultrasound-mediated microbubble and EA-10. Concentration of EA-10 in prostate was measured after the prostate was taken and homogenated. Results： Concentration of EA-10 in treatment group as higher than that of in model group（P〈0.01）. But more EA-10 was measured in ultrasound-mediated microbubble group than in treatment group（P〈0.05）. Conclusion： Ultrasound-mediated microbubble can markedly promote the increase in the drug concentration in rat prostate.

关 键 词：舍尼通 药物浓度 大鼠 超声 微泡 前列腺 EA-10 

分 类 号：R697.33[医药卫生—泌尿科学]