溶胶凝胶法制备TiO_2/HA复合生物活性涂层及其体外活性  

Hydroxyapatite/Titania Composite Coating Processed by Sol–Gel Method and Its Bioactivity in Vitro

作　　者：韩建业[1,2] 于振涛[2] 周廉[2] 

机构地区：[1]西北工业大学,陕西西安710072 [2]西北有色金属研究院,陕西西安710016

出　　处：《稀有金属材料与工程》2008年第A04期551-554,共4页Rare Metal Materials and Engineering

基　　金：西安市863成果转化专项(ZH06002);国家重点基础研究发展计划(2005CB623904)

摘　　要：通过溶胶凝胶法在纯钛基体上制备了羟基磷灰石(HA)/TiO2复合生物活性涂层。HA和TiO2溶胶由前驱体制得,按不同摩尔比直接混合两种溶胶来制备混合溶胶。HA可以提高钛基的生物活性,TiO2可以提高涂层与基体的物理、化学相容性和结合强度。粘结拉伸结果表明,复合涂层与基体结合良好,比纯HA涂层与基体的结合强度提高约47%。复合涂层试样于SBF中浸泡4、7和14d的SEM分析结果表明,复合涂层表面的类骨磷灰石生成量较高。成骨细胞实验结果表明,复合涂层上细胞铺展良好。Hydroxyapatite/titania composite material was coated onto a titanium （pure Ti） substrate by sol-gel method. The HA （Hydroxyapatite） and TiO2 sol were made from precursor and mixed together. The HA was employed to enhance the bioactivity of the Ti substrate, and the TiO2 was to improve the chemical consistency and the bonding strength between the coating and substrate. The HA/TiO2 composite coating adhered tightly to the Ti substrate. The insertion of TiO2 enhanced chemical affinity and physical consistency between HA and Ti substrate. With the insertion of TiO, the crystallinity of HA had been delayed. The specimens with HA/TiO2 composite coating was soaked into SBF for 4, 7, 14 d, and the composite HA coating surface is completely covered by the apatite layer. The composite HA film coated on the pure titanium substrate display good bone like apatite forming ability in SBF. The bioactivity of the composite HA coatings were tested by in vitro cellular culture.

关 键 词：溶胶凝胶法 羟基磷灰石 TiO2 复合涂层 体外活性 

分 类 号：TB33[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]