儿童先天性胆管扩张症胆囊粘膜增殖性变化观察  

MUCOSAL PROLIFERATION CHANGES IN BILIARY TRACT WITH CONGENITAL BILIARY DILATION IN CHILDREN

作　　者：张大江[1] 肖现民[1] 陈莲[1] 周丽君[1] 

机构地区：[1]上海医科大学儿科医院,上海200032

出　　处：《肝胆外科杂志》1998年第4期203-204,共2页Journal of Hepatobiliary Surgery

摘　　要：目的为观察儿童胆管扩张症胆囊粘膜的增殖性变化。方法35例儿童先天性胆管扩张症分为囊形扩张和梭形扩张组，设5例对照组。石蜡切片行HE和增殖细胞核抗原（PCNA）免疫组化染色，观察胆囊粘膜的病理形态，统计形态指标和PCNA阳性率。结果形态指标包括粘膜皱维高度、皱壁密度、皱努细胞密度以及PCNA阳性率均高于对照组，P＜0．05。梭形、囊形之间未见显著差别。结论先天性胆管扩张症在儿童期即有胆囊粘膜增殖性增强，该增殖性变化在胆管梭形、囊形扩张病例之间无明显差别。To investigate the proliferative activities of gallbladder mucosa of congenital binary dilation (CBD) in children. Method Tissue section from 35 CBD and 5 control groups were examined histologically with HE and PCNA staining for PCNA positive percentage and morphological indexes which included mucosal villus height,villus density and villus cell density.Results All the three morphological indexes and PCNA positive percentage were significantly greater than those of control group,while there was no difference between fusiform type and cyst type. Conclusion increased proliferative activities of the binary tract mucosa in CBD have already been observed in childhood. Between fusiform and cyst type in children's CBD,these activities show no difference.

关 键 词：先天性 胆管扩张症 增殖性 PCNA 儿童 

分 类 号：R726.573[医药卫生—儿科]