PLLA纳米纤维编织缝合线的制备及生物相容性研究  

Preparation biocompatibility evaluation on plla braided nanofibers suture

作　　者：胡雯[1] 黄争鸣[2] 唐亮[3] 

机构地区：[1]同济大学材料科学与工程学院,上海200092 [2]同济大学航空航天与力学院,上海200092 [3]同济大学附属上海肺科医院中心实验室,上海200433

出　　处：《功能材料》2009年第11期1888-1891,1899,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(50773054)

摘　　要：以PLLA为原料,采用静电纺丝和圆盘定向收集得到具有有序排列的纳米纤维束,并将其编织成线,得到PLLA纳米纤维缝合线。对新型可吸收PLLA缝线的微观形貌、血液相容性、细胞毒性进行了性能表征,并测试了其力学性能。结果表明,纳米纤维在一定的圆盘转速下表现出较好的定向性,力学性能良好。缝线在溶血试验中溶血率<5%,符合医用材料的溶血要求。MTT实验结果表明缝线材料无细胞毒性,且显示出较高的增殖率,说明新型可吸收PLLA纳米纤维缝线具有良好的生物相容性和安全性。PLLA nanofibers was collected by eleetrospinning and directional collecting disc was used in this experiment, braided suture was fabricated by mini-knitting machine. Micromorphology, blood compatibility, cells toxicity test were characterized of this new type of absorbable PLLA suture. The results show that nanofibers show better directing property in a certain rotating speed and perform favorable mechnical properties. Hemolysis ratio is less than 5% in hemolysis experiment which reach the standard required. There is no cells toxicity of sutures materials and indicative of superior ceils proliferation ratio which makes the explaination of PLLA nanofibers suture of favorable biocompatibility and safety.

关 键 词：聚乳酸 静电纺丝 定向排列 生物相容性 

分 类 号：TQ050.425[化学工程] R318.08[医药卫生—生物医学工程]