显微镜下多血管炎并发肺肾综合征五例临床分析  

Pulmonary renal syndromes associated with microscopic polyangiitis：analysis of five cases

作　　者：徐益明[1] 金美玲[1] 

机构地区：[1]复旦大学附属中山医院呼吸内科,上海200032

出　　处：《临床内科杂志》2009年第11期759-761,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨显微镜下多血管炎（MPA）并发肺肾综合征的临床特点、诊断和治疗，以提高临床诊治水平。方法回顾性总结中山医院2005～2008年MPA并发肺肾综合征5例患者的临床资料，并结合文献对其临床表现、诊治方法进行分析。结果MPA并发的肺肾综合征临床表现不特异，髓过氧化酶阳性和（或）肾组织活检对其确诊意义重大。主要治疗手段为环磷酰胺、甲基泼尼松龙和血浆置换联合治疗。结论及时诊断、正确治疗是改善其预后的关键。Obsjective To study the clinical characteristics, diagnosis and treatment of. Pulmonary renal syndromes associated with microscopic polyangiitis. Methods Five cases of Pulmonary renal syndromes diagnosed from 2005 to 2008 were retrospectively analyzed, and the relevant literatures were reviewed. Results It＇ s manifestations are lack of specific characteristis. Characteristic histology on biopsy and/or a postitive ELISA for MPO antibodies are helpful to identify the disease. Treatment medalities included intravenous cyclophosphamide, pulsed intravenous methylprednisolone combined with plasma exchange. Conclusion The ealy diagnosis and appropriated treatment are essential to optimizing outcomes.

关 键 词：显微镜下多血管炎 肺肾综合征 抗中性粒细胞浆抗体 

分 类 号：R593.2[医药卫生—内科学]