含二肽的新型糖基氨基硫脲的合成(英文)  

Synthesis of New Glycosyl-aminothioureas Containing Dipeptides

作　　者：周树宝[1] 钱兆生[1] 周传健[2] 曹玲华[1] 

机构地区：[1]新疆大学化学化工学院,新疆乌鲁木齐830046 [2]山东大学材料科学与技术学院,山东济南250061

出　　处：《新疆大学学报（自然科学版）》2009年第4期383-393,471,共12页Journal of Xinjiang University(Natural Science Edition)

基　　金：supported by the National Natural Science Foundation of China(Grant No.20462006);Xinjiang Key Laboratory of Plant Resources & Natural Products Chemistry

摘　　要：由N-苄氧羰基-L-氨基酸与氨基酸甲酯作用，再进一步肼解得到N-苄氧羰基-二肽酰肼。将N-苄氧羰基-二肽酰肼与糖基异硫氰酸酯反应，得到一系列新型的N-糖基-2-（N-苄氧羰基-二肽）-氨基硫脲（1a-11，2a-21，3a-31）。新化合物的结构经IR，^1HNMR，MS谱和元素分析确证。A series of new N-glycosyl-2-（N-Cbz-dipeptide）-amino-thioureaes （1a-1l, 2a-21, 3a-31） were obtained from the reaction of glycosyl isothiocyanates and N-Cbz-dipeptide hydrazides. The N-Cbz- dipeptidehydrazides were prepared from the treatment of N-Cbz-L-amino-acids with amino-acid methyl esters, followed by hydrazinolysis. The structures of the new compounds were confirmed by IR, ^1H NMR, MS and elemental analysis.

关 键 词：糖基异硫氰酸酯 二肽 酰肼 糖基氨基硫脲 

分 类 号：O623.76[理学—有机化学]