辛硫磷类似物的合成及杀螺活性  

Synthesis and Molluscicidal Activity of Phoxim Analogues

作　　者：赵青霞[1] 高琼[1] 严相平[1,2] 戴建荣[3] 王浦海[2] 

机构地区：[1]南京工业大学药学院,南京210009 [2]南京工业大学江苏省药物研究所,南京210009 [3]江苏省血吸虫病防治研究所,江苏无锡214064

出　　处：《农药》2009年第11期795-796,820,共3页Agrochemicals

基　　金：江苏省社会发展科技计划项目(BS2007060)

摘　　要：为寻找新的高效、低毒灭螺药,以取代苯乙腈为原料,经成肟、硫代磷酰化等反应,制得9个辛硫磷类似物(2a～2i),其结构经元素分析、IR、1H NMR和MS确证。初步杀螺筛选结果表明:化合物2a、2b、2h具有显著的杀螺活性,其半数致死浓度LC50值分别为0.31、0.33、0.38mg/L。In order to search for novel more effective and less toxic molluscicides,nine new phoxim analogues（2a-2i） were synthesized from substituted phenylacetonitriles by oximation and thiophosphorylation. All compounds were confirmed by elemental analyses,IR,1HNMR and MS. Preliminary biological screening showed that compounds 2a,2b and 2h appeared to have significant molluscicidal activity against Oncomelanis hwpensis snails. The LC50 of the compounds 2a,2b and 2h against snails were 0.31,0.33 and 0.38 mg/L,respectively.

关 键 词：辛硫磷类似物 合成 钉螺 杀螺活性 

分 类 号：TQ453.2[化学工程—农药化工]