云南省某县HIV感染者Ⅱ型单纯疱疹病毒感染及高危性行为研究  

Study on herpes simplex virus 2 infection and risky sexual behavior among HIV-infected patients in a county of Yunnan province

作　　者：傅卓华[1] 高眉扬[1] 陈莉[1] 康永然[2] 杨建华[2] 何纳[1] 

机构地区：[1]复旦大学公共卫生学院流行病学教研室,上海200032 [2]云南省盈江县疾病预防控制中心

出　　处：《中华流行病学杂志》2009年第11期1139-1142,共4页Chinese Journal of Epidemiology

基　　金：上海市重点学科建设项目（B118）

摘　　要：目的了解云南省某县HIV感染者中Ⅱ型单纯疱疹病毒（HSV-2）感染率、HSV-2感染相关因素及高危性行为情况。方法从常规随访的HIV感染者中招募研究对象，问卷调查收集人口学、行为学信息，采集血标本检测HSV-2抗体和CD4^＋T淋巴细胞计数。结果共招募研究对象300人，其中105人检测为HSV-2抗体阳性，感染率为35．0％。多因素logistic回归模型显示，傣族（OR=0．300，95％CI：0．152—0．593）和景颇族（OR=0．376，95％CI：0．167～0．850）HIV感染者HSV-2感染风险低于汉族；经性途径感染HIV者HSV-2感染风险高于经注射吸毒感染HIV者（OR=4．244，95％CI：1．924～9．364）。105人合并感染HIV和HSV-2，其中60人最近3月内有性行为，未坚持使用或不使用安全套者占有性行为者的41．7％，主要见于婚内性行为。结论HIV感染者中HSV-2感染率较高,HIV／HSV-2合并感染者中有不安全性行为者比例高。Objective To explore the sero-prevalence and risk factors for herpes simplex virus 2 （HSV-2） infection and unprotected sexual behavior in an ethnically diverse population of HIV- infected subjects in a county of Yunnan province. Methods HIV-infected individuals attending for routine follow-up by local Center for Disease Control and Prevention （CDC） were recruited to participate in the study under ＇informed consent＇. A face-to-face questionnaire interview was administered to each participant. Blood was drawn for HSV-2 testing by HerpeSelect HSV-2 ELISA （Focus Diagnostics） and CD4^＋ T counting. Results A total of 300 HIV-infected individuals participated in the study. The mean age of the subjects was 37.6 years with 76.7% as males. Ethnically, Han, Dai and Jingpo accounted for 44.3%, 37.3% and 16.0% of the sample, respectively. Half of the subjects reported HIV acquisition through injection drug use. The sero-prevalence of HSV-2 was 35.0%. Results from multiple logistic regression analysis indicated that individuals who acquired HIV through heterosexual contact were more likely to be HSV-2 positive than those who acquired HIV through injection drug use （OR=4.244,95%CI： 1.924-9.364）,whereas Dai （OR= 0.300, 95%CI： 0.152-0.593） and Jingpo （OR=0.376, 95%CI： 0.167-0.850） were less likely to be HSV-2 positive than the Hans. Among 105 people who were co-infected with HIV/HSV-2, 60 had sexual intercourses in the past 3 months and 41.7% of them reported no or inconsistent use of condoms. Most unprotected sexual contacts occurred within married couples. Conclusion HSV-2 infection was highly prevalent among HIV-infected individuals in this county, and a significant proportion of HIV/HSV-2 co-infected subjects engaged in unprotected sex. HSV-2 testing, behavioral and biomedical interventions among HIV-infected individuals and their sexual partners should be involved in the local HIV prevention and control programs.

关 键 词：艾滋病病毒感染 Ⅱ型单纯疱疹病毒 高危性行为 

分 类 号：R51[医药卫生—内科学]