449株病原菌耐药性分析  

Drug Resistance of 449 Pathogenic Strains

作　　者：陈燕清[1] 黄丽芬[1] 陈万山[1] 张复春[1] 

机构地区：[1]广州市第八人民医院医务科,广东广州510060

出　　处：《中华医院感染学杂志》2009年第21期2989-2991,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解医院2008年临床分离常见病原菌分布及对常用抗菌药物的耐药情况。方法采用纸片扩散法进行抗菌药物敏感性试验,以WHONET5.3软件分析耐药性监测数据。结果449株临床分离病原菌中,革兰阳性菌208株(46.32%),革兰阴性菌241株(53.67%);耐甲氧西林金黄色葡萄球菌和耐甲氧西林凝固酶阴性葡萄球菌检出率分别为41.7%和55.0%,未发现万古霉素耐药株;肠杆菌科菌中大肠埃希菌和肺炎克雷伯菌产ESBLs株的检出率分别为41.4%和44.2%,对碳青酶烯类抗菌药物高度敏感;鲍氏不动杆菌、铜绿假单胞菌对碳青酶烯类抗菌药物仍高度敏感。结论开展连续的耐药性监测,可为指导临床合理使用抗菌药物、控制感染提供有力依据。OBJECTIVE To find out the distribution and durg resistance of the pathogens in 2008 in the 8th People＇ s Hospital of Guangzhou. METHODS Disc diffusion test （KB methods） was employed to study the antimicrobial susceptibility. WHONET 5.3 was applied for date analysis. RESULTS 208 Gram positive coccus strains accounted for （46. 3%）, 241 Gram negative bacillus strains （53. 67%） in A total of 449 pathogenic strains. Meticillin resistant strains accounted for 41.7 % and Staphylococcus aureus and CNS for 55%. All the Staphylococcus strains were not Vancomycin-resistance. Escherichia coil and Klebsiella pnenmoniae strains producing extended spectrum-beta-lactamas accounted for 41.4% and 44.2 %, but were highly sensitive to Carbapenem. Acinetobacter baumannii and Pseudomonas aeruginosa were highly sensitive to Carbapenem. CONCLUSIONS The resistance of antibiotics should be continuously monitored to provide basis for reasonable use of drugs in clinical practice and take effective evidence for the control of the problem.

关 键 词：病原菌 耐药性 分析 

分 类 号：R378[医药卫生—病原生物学]