富血小板血浆(PRP)对软骨修复的影响  

EFFECT OF PLATELET-RICH PLASMA (prp) ON CARTILAGE REPAIRING

作　　者：王清义[1] 白晓丹[1] 关富龙[1] 张宝第[1] 杨晓霞[1] 李华阳[1] 刘佳佳[1] 王磊[1] 迟剑萍[1] 周斌[1] 高春阳[1] 

机构地区：[1]牡丹江医学院附属红旗医院骨科,黑龙江牡丹江157011

出　　处：《牡丹江医学院学报》2009年第5期20-26,共7页Journal of Mudanjiang Medical University

基　　金：黑龙江省卫生厅科研课题(2007-048)

摘　　要：目的:探讨大白兔富血小板血浆(PRP)对软骨修复的影响。方法:构建大白兔关节软骨和耳廓软骨损伤模型,每只大白兔本身分左(L)右(R)组,以L组为对照组、R组为治疗组,用大白兔自体的PRP局部注射,2、4、8周后分别取材,通过大体观察、组织学病理切片、图像分析观察软骨损伤修复情况。结果:各期治疗组(R组)软骨损伤的修复明显好于对照组(L组)。结论:PRP对软骨修复有着积极的促进作用,应用PRP可以提高软骨损伤的修复效果。为此提示:临床上可使用PRP治疗膝关节半月板损伤、骨性关节病方面的观察和研究。为临床软骨损伤类疾病探索新的治疗方法和手段。Objeodve：To study the effect of platelet -rich plasma（PRP） on cartilage repairing in white rabbits. Methods：We had constructed a model of cartilaginous trauma with cartilage of joint and auricle, the white rabbits was derided into right（R） and left（L） sides. Right side（R） was randomly chosen as the experimental side, which was locally injected PRP in rabbits. The other side （L）was regarded as the control. After 2,4 and 8 weeks of implantation, the gross, histologicai observations, and computer graphic analysis were performed to investigate the cartilage healing of the trauma in both sides. Results：The repairs of the cartilaginous trauma in all phases were prior to the controls. Conclusion：The cartilaginous trauma is actively effective on the repair of PRP. The damnifications of meniscus in knee joint and the osteal arthropathies with PRP were observed and studied in clinic. The new means will be explored in the diseases about cartilaginous trauma.

关 键 词：富血小板血浆(PRP) 富血小板凝胶(PRG) 生长因子 软骨损伤 修复 

分 类 号：R318[医药卫生—生物医学工程]