血浆皮质醇激素抑制素水平与冠心病的关系  

Relationship between plasma cortistatin and coronary heart disease

作　　者：田清平[1] 冯雪茹[1] 庞永正[2] 唐朝枢[2] 刘梅林[1] 

机构地区：[1]北京大学第一医院老年科,北京100034 [2]北京大学第一医院心血管疾病研究所,北京100034

出　　处：《北京大学学报（医学版）》2009年第5期537-540,共4页Journal of Peking University:Health Sciences

摘　　要：目的:研究血浆皮质醇激素抑制素水平与冠心病的关系及其影响因素。方法:用酶联免疫法测定40例健康对照组和39例冠心病患者行经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术前和术后1 d的皮质醇激素抑制素(cortistatin,CST)水平,比较冠心病组PCI术前和术后1 d与对照组之间血浆CST水平和其他临床资料的差异,进一步分析其相关因素。结果:冠心病组PCI术前和术后1 d血浆CST水平均显著高于对照组(1.97±1.12,2.01±0.77vs1.21±0.27,P<0.01);PCI术前和术后1 d CST无明显差异(1.97±1.12vs2.01±0.77,P>0.05);空腹血糖、超敏C反应蛋白、左心室射血分数、冠状动脉病变评分和高血压病史与CST水平均无明显相关性(均P>0.05);甘油三酯、总胆固醇与CST水平呈负相关(β=-2.594,P<0.05和β=-0.650,P<0.01);心肌梗死病史、糖尿病病史与CST水平呈正相关(β=4.149和β=6.430,P<0.05);合并糖尿病组和有心肌梗死病史组分别比无糖尿病组和无心肌梗死病史组的CST水平高,但是差异没有统计学意义(2.07±1.07vs1.85±1.20;2.20±1.53vs1.79±0.66,P>0.05)。结论:冠心病患者血浆CST水平显著升高,CST可能在冠心病的发生、发展中发挥一定作用。Objective： To analyze the relationship between plasma level of cortistatin （CST） and coronary heart disease （CHD） and the factors that influence the level of CST. Methods： Plasma levels of CST were measured using ELISA method. The clinical data and the levels of CST of 40 healthy subjects and 39 CHD patients before and 1d after percutaneous coronary intervention （PCI） were compared. And the factors that influenced the CST level were analyzed. Results： The CST levels of CHD group before or 1 d after PCI were significantly higher than those of the control group （ 1.97± 1.12 and 2.01 ±0.77 vs 1.21±0. 27 ,P 〈0.01 ） ;The procedure of PCI didn＇ t influence the CST levels（ 1.97 ±1.12 vs 2. 01 ± 0.77,P 〉 0. 05 ） ; There was no correlation between CST levels and fasting blood glucose （FBG） , high sensitivity C-reactive protein （ hsCRP）, left ventricular ejection fraction （ LVEF）, severity of lesions of coronary arteries or history of hypertension; The levels of triglyceride （TG） and total cholesterol （TCHOL） negatively correlated with CST levels（β = - 2. 594, P 〈 0.05 ; and β = - 0. 650, P 〈 0. 01 ）, but history of diabetes mellitus（DM） or myocardial infarction（MI） positively correlated with CST levels （β =4. 149 and 6. 430 ,P 〈 0.05 ）. The CST level of subgroup of CHD with DM or MI was higher than that of CHD without DM or MI, but the difference was not significant （2. 07 ± 10.7 vs 1.85 ±1.20; 2.20 ±1.53 vs 1.79 ± 0. 66, P 〈 0. 05 ）. Conclusion： Patients with CHD have higher plasma levels of CST. CST may play an important role in the procedure of CHD.

关 键 词：神经肽类 冠状动脉疾病 血管成形术 经腔 经皮冠状动脉 皮质醇激素抑制素 

分 类 号：R541.4[医药卫生—心血管疾病]