曲美他嗪对不稳定型心绞痛患者经皮冠状动脉介入治疗的心肌保护作用  

The Effect of Trimetazidine on Serum Level of cTnI and MDA in Unstable Angina Pectoris Patients after PCI

作　　者：罗福全[1] 何兆初[1] 王玮[1] 罗惠玲[1] 曾佩[1] 

机构地区：[1]广州医学院第一附属医院心内科,广东广州510120

出　　处：《广州医学院学报》2009年第4期1-4,共4页Academic Journal of Guangzhou Medical College

基　　金：广东省自然科学基金(00400870)

摘　　要：目的:探讨曲美他嗪对经皮冠状动脉介入治疗(PCI)患者的心肌保护作用及其可能机制。方法:选择不稳定型心绞痛患者42例随机分为两组,常规治疗基础上术前加服曲美他嗪行PCI术21例为曲美他嗪组,不加服曲美他嗪行PCI术21例为对照组。两组均检测PCI术前、术后1 h、6 h、12 h、24 h的血清cTnI和MDA水平。结果:曲美他嗪组和对照组术后6 h、12 h和24 h的cTnI水平均较术前升高(P均<0.05);对照组在术后12 h和24 h升高幅度较曲美他嗪组更大(P均<0.05)。两组PCI术后各时间点MDA均较术前升高(P均<0.05);对照组在PCI术后12 h和24 h时MDA水平增加幅度较曲美他嗪组更大(P分别<0.05和<0.01)。结论:曲美他嗪能减少膜脂质的过氧化损伤,从而减轻PCI造成的心肌细胞损伤,为PCI患者提供心脏保护。Objective：To observe the effect of trimetazidine on blood levels of cTnI and malondialdehyde（MDA） in unstable angina pectoris（UAP） patient after percutaneous coronary intervention（PCI） and investigate the effect of trimetazidine and its protective mechanism after PCI. Methods： 42 patients with unstable angina were randomly divided into the experiment group and the contral group. On the basis of routine treatment,21 patients of the experiment group were treated with trimetazidene before PCI. 21 patients of the control group were treated by PCI. cTnI and MDA levels were measured before and t h,6 h,12 h and 24 h after PCI. Result： The level of cTnI in two groups at 6 h,12 h and 24 h after PCI were significantly higher than before PCI （ P 〈 0.05 ）. And there was significant difference between two groups at 12 h and 24 h after PCI, the elevated cTnI value was significantly lower in the tfimetazidine group than in the contral group（P 〈 0.05 ）. MDA was significantly increase in two groups at each time point post-PCl compared to pre-PCI（ P 〈 0.05 ）, and it was higher in the cotral group than in the tfimetazidine group at 12 h and 24 h two points post-PCI （P 〈 0.05 ）. Conclusion： Trimetazidine administered before PCI may limit oxygen free radical produced so as to limit lipid peroxidation which appears to be a eardioproteetive agent for the prevettion of myocardioal ischaemia.

关 键 词：经皮冠状动脉介入治疗术 不稳定型心绞痛 曲美他嗪 肌钙蛋白I 丙二醛 

分 类 号：R541.4[医药卫生—心血管疾病]