前列腺素衍生物对去卵巢大鼠骨质疏松的治疗作用  

Effects of prostaglandin on osteoporosis in ovariectomized rats

作　　者：刘钰瑜[1] 崔燎[1] 姚卫民[2] 许碧莲[1] 吴铁[1] 

机构地区：[1]广东医学院药理学教研室,广东湛江524023 [2]广东医学院呼吸疾病研究所,广东湛江524001

出　　处：《中国药理学通报》2009年第10期1327-1330,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30672470);广东省教育厅育苗工程资助项目(No08-NYM-061)

摘　　要：目的观察前列腺素衍生物米索前列醇对去卵巢大鼠骨质疏松的治疗作用。方法10mon大鼠双侧卵巢去除,术后2mon开始用药物治疗,用药时间为2mon。用骨组织形态计量学方法测定大鼠第4腰椎松质骨静态、动态参数,大鼠第5腰椎体应用骨生物力学方法作椎体压缩试验。结果在去卵巢引起大鼠骨量降低的情况下,米索前列醇可使去卵巢大鼠骨小梁面积(%Tb.Ar)增加21.6%,但与去卵巢组相比,差异无统计学意义;米索前列醇可改善骨质疏松大鼠椎骨的生物力学状况,表现在能使去卵巢大鼠的破坏应力和弹性模量增加。结论前列腺素衍生物米索前列醇对去卵巢大鼠椎骨的生物力学状况有改善作用。Aim To investigate the preventive effects of misoprostol on osteoporosis in aged ovarieetomized（OVX） rats. Methods Female, 10-month-old SD rats were ovariectomized （ OVX ） and , 2 months later , were treated with misoprostol or controls for 2 months. The static and dynamic parameters in trabecular bone of the forth lumbar vertebrae （LV4）were examined with histomorphometrieal analyses; the fifth lumbar vertebrae （LV5） was used to perform the compression test. Resuits Compared with the data from the sham-operated rats, the percent trabecular area and elastic modulus significantly decreased in OVX rats. Correspondingly, the bone break load and break OVX was compared with those stress decreased of post of sham-operated rats.Misoprostol increased the percent trabecular area by 21.6% compared with OVX rats,but it couldn＇t meet the statistical significance. Misoprostol enhanced the break load and elastic modulus compared with OVX rats. Conclusion Misoprostol can improve biomechanics of bone in ovariectomized osteoporosis rats.

关 键 词：前列腺素 米索前列醇 骨组织形态计量学 骨生物力学 大鼠 骨质疏松 

分 类 号：R332[医药卫生—人体生理学] R336[医药卫生—基础医学]