肿瘤坏死因子相关凋亡诱导配体在寻常型银屑病皮肤中的表达  

The expression of TRAIL in psoriatic patients and healthy subjects

作　　者：杨积顺[1] 吴建华[2] 朱全刚[1] 刘继勇[1] 胡晋红[1] 

机构地区：[1]第二军医大学长海医院药学部,上海200433 [2]第二军医大学长海医院皮肤科,上海200433

出　　处：《中国药理学通报》2009年第10期1338-1340,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30873128)

摘　　要：目的探讨肿瘤坏死因子相关凋亡诱导配体[tumornecrosis factor(TNF)-related apoptosis-inducing ligand,TRAIL]在寻常型银屑病和健康人皮肤组织中的表达差异。方法采用免疫组织化学和Real-Time PCR方法从蛋白水平和mRNA水平上考察TRAIL的表达变化。结果银屑病皮损中肿瘤坏死因子相关凋亡诱导配体的表达低于健康人皮肤。结论TRAIL水平的降低可能与银屑病的发生发展有关。Aim To explore the expression of TNF-re- lated apoptosis-inducing ligand （TRAIL） between psoriatic patients and healthy subjects. Methods Immunohistochemical staining and Real-Time PCR methods were established to detect the expression of TRAIL. Resuits Immunohistochemical staining results indicated a significant difference of the expression of TRAIL between psoriatic patients and healthy subjects. Real-Time PCR results indicated that the quantities were 0. 42 ± 0. 07, 1.01 ± 0. 16 respectively of two type skins. Thus there were significant differences （P 〈 0.01 ）. Conclusion TRAIL might play an important role in the pathogenesis of psoriasis.

关 键 词：TNF相关凋亡诱导配体 银屑病 皮肤 皮损组织 炎症 凋亡 

分 类 号：R322.991[医药卫生—人体解剖和组织胚胎学] R329.25[医药卫生—基础医学]