儿童蛋白丢失性肠病的临床及病理分析  

Clinical and pathologic features of protein-losing enteropathy in children

作　　者：刘艳[1] 黄志华[1] 徐三清[1] 黄永健[1] 董永绥[1] 吴薇[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,湖北武汉430030

出　　处：《临床儿科杂志》2009年第10期938-941,共4页Journal of Clinical Pediatrics

摘　　要：目的探讨蛋白丢失性肠病的病因、内镜下表现及相应的病理特点,提高对儿童蛋白丢失性肠病的认识。方法回顾性分析华中科技大学同济医学院附属同济医院儿科病房2005年2月-2008年4月诊断的8例蛋白丢失性肠病,总结其临床表现、内镜及病理特点。结果原发性肠淋巴管扩张症、克罗恩病、溃疡性结肠炎、嗜酸性粒细胞性胃肠炎、过敏性紫癜等是蛋白丢失性胃肠病的主要病因,腹泻、浮肿及发热为其主要临床表现,内镜、病理及超微病理检查结果具有特异性,治疗效果与病因相关。结论蛋白丢失性肠病诊治困难,病因较多,内镜和活体组织病理检查有助于提高儿童蛋白丢失性肠病的病因诊治水平。Objective To explore the etiological factors, endoscope characteristics and the pathologic features of protein-losing enteropathy in children. Methods Clinical manifestations, endoscope and pathologic characteristics of eight patients diagnosed with protein-losing enteropathy from Feb. 2005 to Apr. 2008 were retrospectively reviewed. Results The main etiological factors of protein-losing enteropathy were primary intestinal lymphangiectasia, Crohn＇s disease, ulcerative colitis, eosinophilic gastroenteritis, and Henoch-Schonlein purpura. The main clinical manifestations are diarrhea, oedema, and fever. The endoscopic, pathological and ultrastructural examinations can find specific features. The prognosis was associated with etiologic factors. Conclusions The diagnosis and treatment of protein-losing enteropathy in children are difficult. The etiological factors are varied. The endoscope examination and biopsy help to improve the diagnosis and treatment.

关 键 词：蛋白丢失性肠病 胃镜 肠镜 病理 

分 类 号：R725.7[医药卫生—儿科]