Quorum-Sensing of Bacteria and Its Application  

作　　者：JIANG Guoliang SU Mingxia 

机构地区：[1]College of Marine Life Sciences, Ocean University of China, Qingdao 266003, P. R. China

出　　处：《Journal of Ocean University of China》2009年第4期385-391,共7页中国海洋大学学报（英文版）

摘　　要：Quorum sensing, or auto induction, as a cell density dependent signaling mechanism in many microorganisms, is trig- gered via auto inducers which passively diffuse across the bacterial envelope and therefore intracellulaly accumulate only at higher bacterial densities to regulate specialized processes such as genetic competence, bioluminescence, virulence and sporulation. N-acyl homoserine lactones are the most common type of signal molecules. Aquaculture is one of the fastest-growing food-producing indus- tries, but disease outbreaks caused by pathogenic bacteria are a significant constraint on the development of the sector worldwide. Many of these pathogens have been found to be controlled by their quorum sensing systems. As there is relevance between the pathogenic bacteria＇s virulence factor expression and their auto inducers, quorum quenching is a new effective anti-infective strategy to control infections caused by bacterial pathogens in aquaculture. The techniques used to do this mainly include the following： （1） the inhibition of signal molecule biosynthesis, （2） blocking signal transduction, and （3） chemical inactivation and biodegradation of signal molecules. To provide a basis for finding alternative means of controlling aquatic diseases by quorum quenching instead of treatment by antibiotics and disinfectants, we will discuss the examination, purification and identification of auto inducers in this paper.

关 键 词：quorum sensing N-acyl homoserine lactones auto inducer quorum quenching 

分 类 号：S948[农业科学—水产养殖] TP751[农业科学—水产科学]