两种方案对治疗幽门螺杆菌感染的疗效比较  

Effects of Two Rescue Regimens on H.pylori Infection

作　　者：代薇[1] 李世媛 周竹[3] 

机构地区：[1]昆明医学院第一附属医院消化内科,云南昆明650032 [2]东川区第二人民医院,云南东川654100 [3]昆明医学院第一附属医院肾内科,云南昆明650032

出　　处：《昆明医学院学报》2009年第10期116-118,共3页Journal of Kunming Medical College

摘　　要：目的探讨三联疗法(质子泵抑制剂+阿莫西林+克拉霉素)根除幽门螺杆菌(HP)治疗失败后的补救方案.方法将97名Hpylori感染且三联疗法根除Hpylori治疗失败的患者,随机分为2组,莫西沙星组:莫西沙星0.4qd,阿莫西林1.0gbid,埃索美拉唑20mgqd;对照组:埃索美拉唑20mgqd,胶态次枸橼酸铋220mgbid,甲硝唑0.4gqd,四环素0.5gtid.治疗7d,治疗结束4w后通过14C-UBT检查Hpylori是否根除,并评价耐受性.结果莫西沙星组Hpylori根除率为87.7%,对照组为70.83%,两组之间的Hpylori根除率差有统计学意义(P<0.05),在依从性和耐受性方面莫西沙星组优于对照组.结论以莫西沙星为基础的三联方案是有效的补救方案,优于四联方案.Objective To observe the ＂rescue＂ regimen after failure of H.pylori eradication with standard triple therapy. Methods In this random control study, 97 H pylori-positive patients with triple therapy （PPI ＋amoxieillin＋elarithmmyein） failure were divided into moxifloxaein （esomeprazole 20 mg qd, moxifloxacin 0.4 g qd, amoxicillin 1.0 g bid） group and control （esomeprazole 20 mg qd, bismuth 220 mg bid, tetracycline 0.5 g bid, metronidazole 0.4 g qd） group. The patients in both groups were treated for 7 days. H pylori status and tolerability were assessed 4 weeks after the end of treatment by 14 C urea breath test and questionary. Results The rates of H pylori eradication in moxifloxacin group and control group were 87.7% and 70.83%, respectively, and there was a difference between them （P 〈 0.05）. Conclusion Seven-day moxifloxaein-based triple therapy is a feasible ＂rescue＂ regimen of H pylori eradication.

关 键 词：幽门螺杆菌 根除 莫西沙星 补救方案 

分 类 号：R969.4[医药卫生—药理学]