白细胞介素33——具有免疫调节作用的白细胞介素1家族新成员  

IL-33,a Novel Member of the IL-1 Family with Immunoregulation Effects

作　　者：刘宁[1] 郑祥雄[1] 

机构地区：[1]福建医科大学附属协和医院临床免疫研究所,福州350001

出　　处：《医学综述》2009年第22期3376-3378,共3页Medical Recapitulate

摘　　要：白细胞介素33(IL-33)是最近通过生物信息学分析发现的一种IL-1家族的细胞因子。IL-33分布广泛,在胃、肺、脊髓、脑和皮肤中高表达,在如Crohn病的患者肠道、类风湿关节炎患者关节滑膜等慢性炎症组织中也能检测到。IL-33具有双重作用,作为分泌性细胞因子能够参与调节Th2免疫反应,并具有前炎性因子的作用;作为核因子则能定位于细胞核内,起转录抑制作用。IL-33在类风湿关节炎等慢性炎性疾病过程中扮演重要角色,对其的研究将为理解这些疾病的发病机制,寻找治疗靶点提供新的思路。Interleukin-33（IL-33）is a kind of cytokine adopted by bioinformatic analysis recently and was designated as a novel member of interleukin-1（IL-1）family.IL-33 is broadly expressed in many tissues.High level of IL-33 is found in the stomach,lung,spinal cord,brain and skin.IL-33 can also be found in chronically inflamed tissues such as Crohn s disease intestine and rheumatoid arthritis（RA）synovium.IL-33 exhibits dual functions,as a secreted cytokines,it can be involved in the regulating of Th2 immune response and has the role of pro-inflammatory cytokines , furthermore,as a nuclear factor, itlocates in the nucleus and inhibits transcription. IL-33 plays an important role in chronically inflammatory diseases such as RA. Exploraltion of the function of IL-33 might shed a light on defining the mechanism of these diseases and finding novel therapeutic targets for the treatment.

关 键 词：白细胞介素33 细胞因子 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]